Contemporary management of muscle-invasive bladder cancer
dc.contributor.author | Dall’Era, Marc A. | |
dc.contributor.author | Cheng, Liang | |
dc.contributor.author | Pan, Chong-Xian | |
dc.contributor.department | Pathology and Laboratory Medicine, School of Medicine | |
dc.date.accessioned | 2025-06-26T15:18:26Z | |
dc.date.available | 2025-06-26T15:18:26Z | |
dc.date.issued | 2012 | |
dc.description.abstract | The current standard treatment for muscle-invasive nonmetastatic bladder cancer is neoadjuvant platinum-based chemotherapy followed by radical cystectomy. However, neoadjuvant chemotherapy is not widely accepted even with level 1 evidence. Adjuvant chemotherapy should be discussed if patients have not received neoadjuvant chemotherapy before surgery and have high-risk pathologic features. Although not considered standard of care, bladder-sparing therapy can be considered for highly selected patients and for those medically unfit for surgery. Even though there are no level 1 data, the treatment outcomes for highly select patients given bladder-sparing therapy appear promising, with many patients retaining a functional bladder. Personalized chemotherapy is currently being actively pursued to target the underlying molecular changes and tailor to individual needs. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Dall'Era MA, Cheng L, Pan CX. Contemporary management of muscle-invasive bladder cancer. Expert Rev Anticancer Ther. 2012;12(7):941-950. doi:10.1586/era.12.60 | |
dc.identifier.uri | https://hdl.handle.net/1805/49009 | |
dc.language.iso | en_US | |
dc.publisher | Taylor & Francis | |
dc.relation.isversionof | 10.1586/era.12.60 | |
dc.relation.journal | Expert Review of Anticancer Therapy | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Bladder urothelial carcinoma | |
dc.subject | Chemotherapy | |
dc.subject | Cisplatin | |
dc.subject | Personalized chemotherapy | |
dc.subject | Targeted therapy | |
dc.title | Contemporary management of muscle-invasive bladder cancer | |
dc.type | Article |