In vitro cytomodulatory and immunomodulatory effects of bovine colostrum whey protein hydrolysates

Date
2021-05
Language
American English
Embargo Lift Date
Committee Members
Degree
Degree Year
Department
Grantor
Journal Title
Journal ISSN
Volume Title
Found At
Wiley
Can't use the file because of accessibility barriers? Contact us with the title of the item, permanent link, and specifics of your accommodation need.
Abstract

Bovine colostrum possesses biological compounds involved in the development of the newborn. Among them, the proteins have drawn attention as a source of bioactive peptides. This study shows the in vitro cytotoxic and immunostimulatory potential of two colostrum whey protein (CWP) hydrolysates obtained by in vitro digestion with pepsin and pancreatin. MTT cell viability, apoptosis induction, polymorphonuclear proliferation and phagocytic activity assays were performed. Treatment with the hydrolysates induced a significant decrease in the viability of MDA-MB-231 cell lines due to apoptosis and also a significant increase in the proliferation of blood mononuclear cells. It could also be observed that for the RM-1 and PC-3 prostate cancer cell lines and for the two times of exposure (24 and 48 h), the hydrolysate H1 is significantly more cytotoxic than CWP. These results showed the potential of bovine CWP and its hydrolysates for the treatment of chronic diseases such as cancer.

Description
item.page.description.tableofcontents
item.page.relation.haspart
Cite As
Fajardo-Espinoza, F. S., Ordaz-Pichardo, C., Sankar, U., Romero-Rojas, A., Moreno-Eutimio, M. A., & Hernández-Sánchez, H. (2021). In vitro cytomodulatory and immunomodulatory effects of bovine colostrum whey protein hydrolysates. International Journal of Food Science & Technology, 56(5), 2109–2121. https://doi.org/10.1111/ijfs.14767
ISSN
0950-5423, 1365-2621
Publisher
Series/Report
Sponsorship
Major
Extent
Identifier
Relation
Journal
International Journal of Food Science & Technology
Source
Author
Alternative Title
Type
Article
Number
Volume
Conference Dates
Conference Host
Conference Location
Conference Name
Conference Panel
Conference Secretariat Location
Version
Author's manuscript
Full Text Available at
This item is under embargo {{howLong}}