Retrospective, observational, cross-sectional study of detection of recurrent Barrett's esophagus and dysplasia in post-ablation patients with adjunctive use of wide-area transepithelial sample (WATS-3D)
dc.contributor.author | Fatima, Hala | |
dc.contributor.author | Wajid, Maryiam | |
dc.contributor.author | Hamade, Nour | |
dc.contributor.author | Han, Yan | |
dc.contributor.author | Kessler, William | |
dc.contributor.author | Dewitt, John | |
dc.contributor.author | Rex, Douglas | |
dc.contributor.author | Imperiale, Thomas | |
dc.contributor.department | Medicine, School of Medicine | en_US |
dc.date.accessioned | 2023-06-06T13:19:05Z | |
dc.date.available | 2023-06-06T13:19:05Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Background: Barrett's esophagus (BE) and dysplasia are often missed by Seattle protocol biopsies (SPB). Wide-area transepithelial sampling with 3-dimensional computer-assisted analysis (WATS-3D) with SPB improves detection in treatment-naïve patients. We aimed to determine to what extent WATS-3D adds to SPB in the detection of non-dysplastic BE (NDBE) and dysplasia in patients undergoing post-endoscopic eradication therapy (EET). Methods: This retrospective, observational, cross-sectional study included patients who presented for post-EET surveillance with SPB and WATS-3D sampling from April 2019 to February 2020. BE patients with no previous EET were excluded. For the outcomes of NDBE and any dysplastic/neoplastic finding, we calculated both relative and absolute increases in yield by WATS-3D over SBP. Results: In 78 patients [mean age 68±10.4 years, 66 (84.6%) male], the prevalence of NDBE, any dysplastic/neoplastic finding, and any abnormality (NDBE or dysplasia/neoplasia) were 53.85%, 10.26%, and 55.13%. The absolute increase in yield of NDBE with WATS-3D over SPB was 26.9% (95% confidence interval [CI] 17.95-37.18%), with the number needed to treat (NNT) 3.71 (95%CI 2.69-5.57) and a relative increase in yield of 100% (95%CI 53.33-188.25%). For dysplasia/neoplasia, the absolute increase in yield was 6.4% (95%CI 1.28-12.82%), NNT 15.6 (95%CI 7.8-78.0), and relative increase of 167% (95%CI 33.33%-infinity). For any abnormal finding, the absolute increase in yield was 26.9% (95%CI 16.67-37.18%), NNT 3.71 (95%CI 2.69-6.00), and relative increase in yield 95% (95%CI 50-176.92%). Conclusions: WATS-3D with SPB improves the detection of residual/recurrent BE and dysplasia in post-ablation BE. However, randomized controlled trials are needed to validate these findings. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Fatima H, Wajid M, Hamade N, et al. Retrospective, observational, cross-sectional study of detection of recurrent Barrett's esophagus and dysplasia in post-ablation patients with adjunctive use of wide-area transepithelial sample (WATS-3D). Ann Gastroenterol. 2022;35(2):113-118. doi:10.20524/aog.2022.0693 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/33515 | |
dc.language.iso | en_US | en_US |
dc.publisher | Hellenic Society of Gastroenterology | en_US |
dc.relation.isversionof | 10.20524/aog.2022.0693 | en_US |
dc.relation.journal | Annals of Gastroenterology | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | PMC | en_US |
dc.subject | Barrett’s esophagus | en_US |
dc.subject | Seattle protocol | en_US |
dc.subject | Dysplasia | en_US |
dc.subject | Detection | en_US |
dc.subject | Post-endoscopic eradication therapy | en_US |
dc.title | Retrospective, observational, cross-sectional study of detection of recurrent Barrett's esophagus and dysplasia in post-ablation patients with adjunctive use of wide-area transepithelial sample (WATS-3D) | en_US |
dc.type | Article | en_US |