Inhibiting oestrogen signalling in pulmonary arterial hypertension: sex, drugs and research

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dc.contributor.authorLahm, Tim
dc.contributor.authorKawut, Steven M.
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2018-03-09T21:44:31Z
dc.date.available2018-03-09T21:44:31Z
dc.date.issued2017-08-03
dc.description.abstractPulmonary arterial hypertension (PAH) is a sexually dimorphic disease that affects women more than men. Several pre-clinical and clinical studies identified 17β-oestradiol (E2), the most abundant female sex hormone, and/or its metabolite 16α-hydroxyoestrone as disease mediators in PAH (reviewed by Lahm et al. [1], and Foderaro and Venteuolo [2]). A recent case–control study even demonstrated significantly higher levels of E2 in men with PAH compared to controls [3]., Inhibition of oestrogen signalling in PAH is currently being studied clinically but several questions remain http://ow.ly/G7xK30cPN5Men_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationLahm, T., & Kawut, S. M. (2017). Inhibiting oestrogen signalling in pulmonary arterial hypertension: sex, drugs and research. The European Respiratory Journal, 50(2). https://doi.org/10.1183/13993003.00983-2017en_US
dc.identifier.issn0903-1936en_US
dc.identifier.urihttps://hdl.handle.net/1805/15428
dc.language.isoen_USen_US
dc.publisherEuropean Respiratory Societyen_US
dc.relation.isversionof10.1183/13993003.00983-2017en_US
dc.relation.journalThe European Respiratory Journalen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectoestrogenen_US
dc.subjectpulmonary arteriesen_US
dc.subjectsexen_US
dc.subjecthypertensionen_US
dc.subjectdrugsen_US
dc.titleInhibiting oestrogen signalling in pulmonary arterial hypertension: sex, drugs and researchen_US
dc.typeArticleen_US
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593373/en_US
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