Integrin α 5 Is Regulated by miR-218-5p in Endothelial Progenitor Cells

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dc.contributor.authorLiu, Jialing
dc.contributor.authorLi, Yi
dc.contributor.authorLyu, Lingna
dc.contributor.authorXiao, Liang
dc.contributor.authorMemon, Aliza A.
dc.contributor.authorYu, Xin
dc.contributor.authorHalim, Arvin
dc.contributor.authorPatel, Shivani
dc.contributor.authorOsman, Abdikheyre
dc.contributor.authorYin, Wenqing
dc.contributor.authorJiang, Jie
dc.contributor.authorNaini, Said
dc.contributor.authorLim, Kenneth
dc.contributor.authorZhang, Aifeng
dc.contributor.authorWilliams, Jonathan D.
dc.contributor.authorKoester, Ruth
dc.contributor.authorQi, Kevin Z.
dc.contributor.authorFucci, Quynh-Anh
dc.contributor.authorDing, Lai
dc.contributor.authorChang, Steven
dc.contributor.authorPatel, Ankit
dc.contributor.authorMori, Yutaro
dc.contributor.authorChaudhari, Advika
dc.contributor.authorBao, Aaron
dc.contributor.authorLiu, Jia
dc.contributor.authorLu, Tzong-Shi
dc.contributor.authorSiedlecki, Andrew
dc.contributor.departmentMedicine, School of Medicine
dc.date.accessioned2023-11-20T15:31:29Z
dc.date.available2023-11-20T15:31:29Z
dc.date.issued2022
dc.description.abstractKidney endothelial cells are sensitive to hypoxic injury. This cell type expresses integrin α5 (ITGA5), which is essential to the Tie2 signaling cascade. The microRNA miR-218 is known to increase after hypoxia, but the microRNA’s role in regulating ITGA5 protein synthesis is unclear. In this study, the authors found that miR-218-5p specifically binds to ITGA5 mRNA in human kidney-derived endothelial progenitor cells (EPCs). In an animal model of ischemia/reperfusion injury, cells pretreated with an miR-218-5p mimic were delivered efficiently, whereas an animal model containing an miR-218-2 deletion specific to angioblasts resulted in kidney dysgenesis and impaired migration of mouse kidney-derived EPCs. Understanding the regulation of prominent signaling pathways in EPCs may inform optimization of therapeutic techniques for addressing kidney endothelial cell injury.
dc.identifier.citationLiu J, Li Y, Lyu L, et al. Integrin α5 Is Regulated by miR-218-5p in Endothelial Progenitor Cells. J Am Soc Nephrol. 2022;33(3):565-582. doi:10.1681/ASN.2021020140
dc.identifier.urihttps://hdl.handle.net/1805/37174
dc.language.isoen_US
dc.publisherWolters Kluwer
dc.relation.isversionof10.1681/ASN.2021020140
dc.relation.journalJournal of the American Society of Nephrology
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectEndothelial cells
dc.subjectRenal ischemia
dc.subjectAcute kidney injury
dc.titleIntegrin α 5 Is Regulated by miR-218-5p in Endothelial Progenitor Cells
dc.typeArticle
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975065/
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