Promoting vascular repair in the retina: can stem/progenitor cells help?

dc.contributor.authorPhuong Trinh, Thao Le
dc.contributor.authorCalzi, Sergio Li
dc.contributor.authorShaw, Lynn C.
dc.contributor.authorYoder, Mervin C.
dc.contributor.authorGrant, Maria B.
dc.contributor.departmentBiochemistry and Molecular Biology, School of Medicineen_US
dc.date.accessioned2018-03-14T16:16:44Z
dc.date.available2018-03-14T16:16:44Z
dc.date.issued2016-05-26
dc.description.abstractSince its first epidemic in the 1940s, retinopathy of prematurity (ROP) has been a challenging illness in neonatology. Higher than physiological oxygen levels impede the development of the immature retinal neuropil and vasculature. Current treatment regimens include cryotherapy, laser photocoagulation, and anti-VEGF agents. Unfortunately, none of these approaches can rescue the normal retinal vasculature, and each has significant safety concerns. The limitations of these approaches have led to new efforts to understand the pathological characteristics in each phase of ROP and to find a safer and more effective therapeutic approach. In the era of stem cell biology and with the need for new treatments for ROP, this review discusses the possible future use of unique populations of proangiogenic cells for therapeutic revascularization of the preterm retina.en_US
dc.identifier.citationTrinh, T. L. P., Li Calzi, S., Shaw, L. C., Yoder, M. C., & Grant, M. B. (2016). Promoting vascular repair in the retina: can stem/progenitor cells help? Eye and Brain, 8, 113–122. http://doi.org/10.2147/EB.S94451en_US
dc.identifier.urihttps://hdl.handle.net/1805/15527
dc.language.isoen_USen_US
dc.publisherDovepressen_US
dc.relation.isversionof10.2147/EB.S94451en_US
dc.relation.journalEye and Brainen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/
dc.sourcePMCen_US
dc.subjectRetinopathy of prematurityen_US
dc.subjectROP therapyen_US
dc.subjectEndothelial progenitor cellsen_US
dc.subjectCD34+ cellsen_US
dc.subjectEndothelial colony-forming cellsen_US
dc.subjectOxygen-induced retinopathyen_US
dc.titlePromoting vascular repair in the retina: can stem/progenitor cells help?en_US
dc.typeArticleen_US
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