Striatal and thalamic GABA level concentrations play differential roles for the modulation of response selection processes by proprioceptive information.

Date
2015-10-15
Language
American English
Embargo Lift Date
Committee Members
Degree
Degree Year
Department
Grantor
Journal Title
Journal ISSN
Volume Title
Found At
Elsevier
Abstract

The selection of appropriate responses is a complex endeavor requiring the integration of many different sources of information in fronto-striatal-thalamic circuits. An often neglected but relevant piece of information is provided by proprioceptive inputs about the current position of our limbs. This study examines the importance of striatal and thalamic GABA levels in these processes using GABA-edited magnetic resonance spectroscopy (GABAMRS) and a Simon task featuring proprioception-induced interference in healthy subjects. As a possible model of deficits in the processing of proprioceptive information, we also included Parkinson's disease (PD) patients in this study.The results show that proprioceptive information about unusual postures complicates response selection processes in controls, but not in PD patients. The well-known deficits of PD patients in processing proprioceptive information can turn into a benefit when altered proprioceptive information would normally complicate response selection processes. Striatal and thalamic GABA levels play dissociable roles in the modulation of response selection processes by proprioceptive information: Striatal GABA levels seem to be important for the general speed of responding, most likely because striatal GABA promotes response selection. In contrast, the modulation of response conflict by proprioceptive information is closely related to thalamic GABA concentrations with higher concentration being related to a smaller response conflict effect. The most likely explanation for this finding is that the thalamus is involved in the integration of sensorimotor, attentional, and cognitive information for the purpose of response formation. Yet, this effect in the thalamus vanishes when controls and PD patients were analyzed separately.

Description
item.page.description.tableofcontents
item.page.relation.haspart
Cite As
Dharmadhikari, S., Ma, R., Yeh, C.-L., Stock, A.-K., Snyder, S., Zauber, S. E., … Beste, C. (2015). Striatal and thalamic GABA level concentrations play differential roles for the modulation of response selection processes by proprioceptive information. NeuroImage, 120, 36–42. https://doi.org/10.1016/j.neuroimage.2015.06.066
ISSN
1053-8119 1095-9572
Publisher
Series/Report
Sponsorship
Major
Extent
Identifier
Relation
Journal
NeuroImage
Rights
Publisher Policy
Source
PMC
Alternative Title
Type
Article
Number
Volume
Conference Dates
Conference Host
Conference Location
Conference Name
Conference Panel
Conference Secretariat Location
Version
Accepted Manuscript
Full Text Available at
This item is under embargo {{howLong}}