Effect of Hesperidin with and without a Calcium (Calcilock®) Supplement on Bone Health in Postmenopausal Women
dc.contributor.author | Martin, Berdine R. | |
dc.contributor.author | McCabe, George P. | |
dc.contributor.author | McCabe, Linda | |
dc.contributor.author | Jackson, George S. | |
dc.contributor.author | Horcajada, Marie Noelle | |
dc.contributor.author | Offord-Cavin, Elizabeth | |
dc.contributor.author | Peacock, Munro | |
dc.contributor.author | Weaver, Connie M. | |
dc.contributor.department | Department of Medicine, IU School of Medicine | en_US |
dc.date.accessioned | 2016-11-02T16:26:50Z | |
dc.date.available | 2016-11-02T16:26:50Z | |
dc.date.issued | 2016-03 | |
dc.description.abstract | Context: Citrus fruits contain unique flavanones. One of the most abundant of the flavanones, hesperidin, has been shown to prevent bone loss in ovariectomized rats. Objective: The objective of the study was to measure the effect of hesperidin with or without calcium supplementation on bone calcium retention in postmenopausal women. Design: The study was a double-blind, placebo-controlled, randomized-order crossover design of 500 g hesperidin with or without 500 mg calcium supplement in 12 healthy postmenopausal women. Bone calcium retention was determined from urinary excretion of the rare isotope, 41Ca, from bone. Results: Calcium plus hesperidin, but not hesperidin alone, improved bone calcium retention by 5.5% (P < .04). Conclusion: Calcium supplementation (Calcilock), in combination with hesperidin, is effective at preserving bone in postmenopausal women. - See more at: http://press.endocrine.org/doi/10.1210/jc.2015-3767#sthash.ztalWWcv.dpuf | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Martin, B. R., McCabe, G. P., McCabe, L., Jackson, G. S., Horcajada, M. N., Offord-Cavin, E., … Weaver, C. M. (2016). Effect of Hesperidin With and Without a Calcium (Calcilock) Supplement on Bone Health in Postmenopausal Women. The Journal of Clinical Endocrinology & Metabolism, 101(3), 923–927. http://doi.org/10.1210/jc.2015-3767 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/11320 | |
dc.language.iso | en | en_US |
dc.relation.isversionof | 10.1210/jc.2015-3767 | en_US |
dc.relation.journal | The Journal of Clinical Endocrinology & Metabolism | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Author | en_US |
dc.subject | hesperidin | en_US |
dc.subject | citrus flavanones | en_US |
dc.subject | calcium retention | en_US |
dc.title | Effect of Hesperidin with and without a Calcium (Calcilock®) Supplement on Bone Health in Postmenopausal Women | en_US |
dc.type | Article | en_US |