Pancreatic Fluid Interleukin-1β Complements Prostaglandin E2 and Serum Carbohydrate Antigen 19-9 in Prediction of Intraductal Papillary Mucinous Neoplasm Dysplasia
dc.contributor.author | Simpson, Rachel E. | |
dc.contributor.author | Yip-Schneider, Michele T. | |
dc.contributor.author | Flick, Katelyn F. | |
dc.contributor.author | Wu, Huangbing | |
dc.contributor.author | Colgate, Cameron L. | |
dc.contributor.author | Schmidt, C. Max | |
dc.contributor.department | Surgery, School of Medicine | en_US |
dc.date.accessioned | 2021-05-24T19:56:20Z | |
dc.date.available | 2021-05-24T19:56:20Z | |
dc.date.issued | 2019-09-01 | |
dc.description.abstract | Objectives: We sought to determine if interleukin (IL)-1β and prostaglandin E2 (PGE2) (inflammatory mediators in pancreatic fluid) together with serum carbohydrate antigen (CA) 19–9 could better predict intraductal papillary mucinous neoplasm (IPMN) dysplasia than individual biomarkers alone. Methods: Pancreatic cyst fluid (n = 92) collected via endoscopy or surgery (2003–2016) was analyzed for PGE2 and IL-1β (Enzyme-Linked Immunosorbent Assay). Patients had surgical pathology-proven IPMN. Threshold values (PGE2 [>1100 pg/mL], IL-1β [>20 pg/mL], serum CA 19–9 [>36 U/mL]) were determined. Results: Levels of IL-1β were higher in high-grade (HGD)/Invasive-IPMN (n = 42) compared to Low/Moderate-IPMN (n = 37) (median [range], 54.6 [0–2671] vs 5.9 [0–797] pg/mL; P < 0.001; Area Under Curve [AUC], 0.766). Similarly, PGE2 was higher in HGD/Invasive-IPMN (n = 45) compared to Low/Moderate-IPMN (n = 47) (median [range], 1790 [20–15,180] vs. 140 [10–14,630] pg/mL; P < 0.001; AUC, 0.748). Presence of elevated PGE2 and IL-1β (AUC, 0.789) provided 89% specificity and 82% positive predictive value (PPV) for HGD/Invasive-IPMN. Elevated levels of all three provided 100% Specificity and PPV for HGD/Invasive-IPMN. Conclusion: Cyst fluid PGE2, IL-1β, and serum CA 19–9 in combination optimize specificity and PPV for HGD/Invasive-IPMN and may help build a panel of markers to predict IPMN dysplasia. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Simpson, R. E., Yip-Schneider, M. T., Flick, K. F., Wu, H., Colgate, C. L., & Schmidt, C. M. (2019). Pancreatic Fluid Interleukin-1β Complements Prostaglandin E2 and Serum Carbohydrate Antigen 19-9 in Prediction of Intraductal Papillary Mucinous Neoplasm Dysplasia. Pancreas, 48(8), 1026–1031. https://doi.org/10.1097/MPA.0000000000001377 | en_US |
dc.identifier.issn | 0885-3177 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/26005 | |
dc.language.iso | en_US | en_US |
dc.publisher | Wolters Kluwer | en_US |
dc.relation.isversionof | 10.1097/MPA.0000000000001377 | en_US |
dc.relation.journal | Pancreas | en_US |
dc.source | PMC | en_US |
dc.subject | intraductal papillary mucinous neoplasm | en_US |
dc.subject | pancreatic cyst | en_US |
dc.subject | interleukin-1β | en_US |
dc.subject | prostaglandin E2 | en_US |
dc.subject | biomarker | en_US |
dc.subject | dysplasia | en_US |
dc.title | Pancreatic Fluid Interleukin-1β Complements Prostaglandin E2 and Serum Carbohydrate Antigen 19-9 in Prediction of Intraductal Papillary Mucinous Neoplasm Dysplasia | en_US |
dc.type | Article | en_US |
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