Genome-wide analysis identifies 12 loci influencing human reproductive behavior

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dc.contributor.authorBarban, Nicola
dc.contributor.authorJansen, Rick
dc.contributor.authorde Vlaming, Ronald
dc.contributor.authorVaez, Ahmad
dc.contributor.authorMandemakers, Jornt J.
dc.contributor.authorTropf, Felix C.
dc.contributor.authorShen, Xia
dc.contributor.authorWilson, James F.
dc.contributor.authorChasman, Daniel I.
dc.contributor.authorNolte, Ilja M.
dc.contributor.authorTragante, Vinicius
dc.contributor.authorvan der Laan, Sander W.
dc.contributor.authorPerry, John R. B.
dc.contributor.authorKong, Augustine
dc.contributor.authorAhluwalia, Tarunveer
dc.contributor.authorAlbrecht, Eva
dc.contributor.authorYerges-Armstrong, Laura
dc.contributor.authorAtzmon, Gil
dc.contributor.authorAuro, Kirsi
dc.contributor.authorAyers, Kristin
dc.contributor.authorBakshi, Andrew
dc.contributor.authorBen-Avraham, Danny
dc.contributor.authorBerger, Klaus
dc.contributor.authorBergman, Aviv
dc.contributor.authorBertram, Lars
dc.contributor.authorBielak, Lawrence F.
dc.contributor.authorBjornsdottir, Gyda
dc.contributor.authorBonder, Marc Jan
dc.contributor.authorBroer, Linda
dc.contributor.authorBui, Minh
dc.contributor.authorBarbieri, Caterina
dc.contributor.authorCavadino, Alana
dc.contributor.authorChavarro, Jorge E
dc.contributor.authorTurman, Constance
dc.contributor.authorConcas, Maria Pina
dc.contributor.authorCordell, Heather J.
dc.contributor.authorDavies, Gail
dc.contributor.authorEibich, Peter
dc.contributor.authorEriksson, Nicholas
dc.contributor.authorEsko, Tõnu
dc.contributor.authorEriksson, Joel
dc.contributor.authorFalahi, Fahimeh
dc.contributor.authorFelix, Janine F.
dc.contributor.authorFontana, Mark Alan
dc.contributor.authorFranke, Lude
dc.contributor.authorGandin, Ilaria
dc.contributor.authorGaskins, Audrey J.
dc.contributor.authorGieger, Christian
dc.contributor.authorGunderson, Erica P.
dc.contributor.authorGuo, Xiuqing
dc.contributor.authorHayward, Caroline
dc.contributor.authorHe, Chunyan
dc.contributor.authorHofer, Edith
dc.contributor.authorHuang, Hongyan
dc.contributor.authorJoshi, Peter K.
dc.contributor.authorKanoni, Stavroula
dc.contributor.authorKarlsson, Robert
dc.contributor.authorKiechl, Stefan
dc.contributor.authorKifley, Annette
dc.contributor.authorKluttig, Alexander
dc.contributor.authorKraft, Peter
dc.contributor.authorLagou, Vasiliki
dc.contributor.authorLecoeur, Cecile
dc.contributor.authorLahti, Jari
dc.contributor.authorLi-Gao, Ruifang
dc.contributor.authorLind, Penelope A.
dc.contributor.authorLiu, Tian
dc.contributor.authorMakalic, Enes
dc.contributor.authorMamasoula, Crysovalanto
dc.contributor.authorMatteson, Lindsay
dc.contributor.authorMbarek, Hamdi
dc.contributor.authorMcArdle, Patrick F.
dc.contributor.authorMcMahon, George
dc.contributor.authorMeddens, S. Fleur W.
dc.contributor.authorMihailov, Evelin
dc.contributor.authorMiller, Mike
dc.contributor.authorMissmer, Stacey A.
dc.contributor.authorMonnereau, Claire
dc.contributor.authorvan der Most, Peter J.
dc.contributor.authorMyhre, Ronny
dc.contributor.authorNalls, Mike A.
dc.contributor.authorNutile, Teresa
dc.contributor.authorPanagiota, Kalafati Ioanna
dc.contributor.authorPorcu, Eleonora
dc.contributor.authorProkopenko, Inga
dc.contributor.authorRajan, Kumar B.
dc.contributor.authorRich-Edwards, Janet
dc.contributor.authorRietveld, Cornelius A.
dc.contributor.authorRobino, Antonietta
dc.contributor.authorRose, Lynda M.
dc.contributor.authorRueedi, Rico
dc.contributor.authorRyan, Kathy
dc.contributor.authorSaba, Yasaman
dc.contributor.authorSchmidt, Daniel
dc.contributor.authorSmith, Jennifer A.
dc.contributor.authorStolk, Lisette
dc.contributor.authorStreeten, Elizabeth
dc.contributor.authorTonjes, Anke
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorUlivi, Sheila
dc.contributor.authorWedenoja, Juho
dc.contributor.authorWellman, Juergen
dc.contributor.authorWilleit, Peter
dc.contributor.authorYao, Jie
dc.contributor.authorYengo, Loic
dc.contributor.authorZhao, Jing Hua
dc.contributor.authorZhao, Wei
dc.contributor.authorZhernakova, Daria V.
dc.contributor.authorAmin, Najaf
dc.contributor.authorAndrews, Howard
dc.contributor.authorBalkau, Beverly
dc.contributor.authorBarzilai, Nir
dc.contributor.authorBergmann, Sven
dc.contributor.authorBiino, Ginevra
dc.contributor.authorBisgaard, Hans
dc.contributor.authorBønnelykke, Klaus
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorBuring, Julie E.
dc.contributor.authorCampbell, Harry
dc.contributor.authorCappellani, Stefania
dc.contributor.authorCiullo, Marina
dc.contributor.authorCox, Simon R.
dc.contributor.authorCucca, Francesco
dc.contributor.authorDaniela, Toniolo
dc.contributor.authorDavey-Smith, George
dc.contributor.authorDeary, Ian J.
dc.contributor.authorDedoussis, George
dc.contributor.authorDeloukas, Panos
dc.contributor.authorvan Duijn, Cornelia M.
dc.contributor.authorde Geus, Eco J. C.
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorEvans, Denis A.
dc.contributor.authorFaul, Jessica D.
dc.contributor.authorFelicita, Sala Cinzia
dc.contributor.authorFroguel, Philippe
dc.contributor.authorGasparini, Paolo
dc.contributor.authorGirotto, Giorgia
dc.contributor.authorGrabe, Hans-Jörgen
dc.contributor.authorGreiser, Karin Halina
dc.contributor.authorGroenen, Patrick J. F.
dc.contributor.authorde Haan, Hugoline G.
dc.contributor.authorHaerting, Johannes
dc.contributor.authorHarris, Tamara B.
dc.contributor.authorHeath, Andrew C.
dc.contributor.authorHeikkilä, Kauko
dc.contributor.authorHofman, Albert
dc.contributor.authorHomuth, Georg
dc.contributor.authorHolliday, Elizabeth G.
dc.contributor.authorHopper, John
dc.contributor.authorHypponen, Elina
dc.contributor.authorJacobsson, Bo
dc.contributor.authorJaddoe, Vincent W.
dc.contributor.authorJohannesson, Magnus
dc.contributor.authorJugessur, Astanand
dc.contributor.authorKähönen, Mika
dc.contributor.authorKajantie, Eero
dc.contributor.authorKardia, Sharon L. R.
dc.contributor.authorKeavney, Bernard
dc.contributor.authorKolcic, Ivana
dc.contributor.authorKoponen, Päivikki
dc.contributor.authorKovacs, Peter
dc.contributor.authorKronenberg, Florian
dc.contributor.authorKutalik, Zoltan
dc.contributor.authorLa Bianca, Martina
dc.contributor.authorLachance, Genevieve
dc.contributor.authorIacono, William
dc.contributor.authorLai, Sandra
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorLiewald, David C.
dc.contributor.authorLindgren, Cecilia
dc.contributor.authorLiu, Yongmei
dc.contributor.authorLuben, Robert
dc.contributor.authorLucht, Michael
dc.contributor.authorLuoto, Riitta
dc.contributor.authorMagnus, Per
dc.contributor.authorMagnusson, Patrik K. E.
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorMcGue, Matt
dc.contributor.authorMcQuillan, Ruth
dc.contributor.authorMedland, Sarah E.
dc.contributor.authorMeisinger, Christa
dc.contributor.authorMellström, Dan
dc.contributor.authorMetspalu, Andres
dc.contributor.authorMichela, Traglia
dc.contributor.authorMilani, Lili
dc.contributor.authorMitchell, Paul
dc.contributor.authorMontgomery, Grant W.
dc.contributor.authorMook-Kanamori, Dennis
dc.contributor.authorde Mutsert, Renée
dc.contributor.authorNohr, Ellen A.
dc.contributor.authorOhlsson, Claes
dc.contributor.authorOlsen, Jørn
dc.contributor.authorOng, Ken K.
dc.contributor.authorPaternoster, Lavinia
dc.contributor.authorPattie, Alison
dc.contributor.authorPenninx, Brenda W. J. H.
dc.contributor.authorPerola, Markus
dc.contributor.authorPeyser, Patricia A.
dc.contributor.authorPirastu, Mario
dc.contributor.authorPolasek, Ozren
dc.contributor.authorPower, Chris
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorRaffel, Leslie J.
dc.contributor.authorRäikkönen, Katri
dc.contributor.authorRaitakari, Olli
dc.contributor.authorRidker, Paul M.
dc.contributor.authorRing, Susan M.
dc.contributor.authorRoll, Kathryn
dc.contributor.authorRudan, Igor
dc.contributor.authorRuggiero, Daniela
dc.contributor.authorRujescu, Dan
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorSchlessinger, David
dc.contributor.authorSchmidt, Helena
dc.contributor.authorSchmidt, Reinhold
dc.contributor.authorSchupf, Nicole
dc.contributor.authorSmit, Johannes
dc.contributor.authorSorice, Rossella
dc.contributor.authorSpector, Tim D.
dc.contributor.authorStarr, John M.
dc.contributor.authorStöckl, Doris
dc.contributor.authorStrauch, Konstantin
dc.contributor.authorStumvoll, Michael
dc.contributor.authorSwertz, Morris A.
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorThurik, A. Roy
dc.contributor.authorTimpson, Nicholas J.
dc.contributor.authorTönjes, Anke
dc.contributor.authorTung, Joyce Y.
dc.contributor.authorUitterlinden, André G.
dc.contributor.authorVaccargiu, Simona
dc.contributor.authorViikari, Jorma
dc.contributor.authorVitart, Veronique
dc.contributor.authorVölzke, Henry
dc.contributor.authorVollenweider, Peter
dc.contributor.authorVuckovic, Dragana
dc.contributor.authorWaage, Johannes
dc.contributor.authorWagner, Gert G.
dc.contributor.authorWang, Jie Jin
dc.contributor.authorWareham, Nicholas J.
dc.contributor.authorWeir, David R.
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorWilleit, Johann
dc.contributor.authorWright, Alan F.
dc.contributor.authorZondervan, Krina T.
dc.contributor.authorStefannson, Kari
dc.contributor.authorKrueger, Robert F.
dc.contributor.authorLee, James J.
dc.contributor.authorBenjamin, Daniel J.
dc.contributor.authorCesarini, David
dc.contributor.authorKoellinger, Philipp D.
dc.contributor.authorden Hoed, Marcel
dc.contributor.authorSnieder, Harold
dc.contributor.authorMills, Melinda C.
dc.contributor.departmentDepartment of Epidemiology, Richard M. Fairbanks School of Public Healthen_US
dc.date.accessioned2017-07-13T15:58:41Z
dc.date.available2017-07-13T15:58:41Z
dc.date.issued2016-10
dc.description.abstractThe genetic architecture of human reproductive behavior—age at first birth (AFB) and number of children ever born (NEB)—has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationBarban, N., Jansen, R., de Vlaming, R., Vaez, A., Mandemakers, J. J., Tropf, F. C., ... & Tragante, V. (2016). Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature genetics. http://doi.org/10.1038/ng.3698en_US
dc.identifier.urihttps://hdl.handle.net/1805/13422
dc.language.isoenen_US
dc.publisherNatureen_US
dc.relation.isversionof10.1038/ng.3698en_US
dc.relation.journalNature Geneticsen_US
dc.rightsPublisher Policyen_US
dc.sourceAuthoren_US
dc.subjectbehavioral geneticsen_US
dc.subjectgenome-wide association studyen_US
dc.titleGenome-wide analysis identifies 12 loci influencing human reproductive behavioren_US
dc.typeArticleen_US
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