The first synthesis of the antiangiogenic homoisoflavanone, cremastranone
| dc.contributor.author | Lee, Bit | |
| dc.contributor.author | Basavarajappa, Halesha D. | |
| dc.contributor.author | Sulaiman, Rania S. | |
| dc.contributor.author | Fei, Xiang | |
| dc.contributor.author | Seo, Seung-Yong | |
| dc.contributor.author | Corson, Timothy W. | |
| dc.contributor.department | Department of Ophthalmology, IU School of Medicine | en_US |
| dc.date.accessioned | 2016-08-23T13:04:49Z | |
| dc.date.available | 2016-08-23T13:04:49Z | |
| dc.date.issued | 2014-10-21 | |
| dc.description.abstract | An antiangiogenic homoisoflavanone, cremastranone, was synthesized for the first time. This scalable synthesis, which includes selective demethylation, could be used to develop lead molecules to treat angiogenesis-induced eye diseases. Synthetic cremastranone inhibited the proliferation, migration and tube formation ability of human retinal microvascular endothelial cells, important steps in pathological angiogenesis. | en_US |
| dc.eprint.version | Author's manuscript | en_US |
| dc.identifier.citation | Lee, B., Basavarajappa, H. D., Sulaiman, R. S., Fei, X., Seo, S.-Y., & Corson, T. W. (2014). First Synthesis of the Antiangiogenic Homoisoflavanone, Cremastranone. Organic & Biomolecular Chemistry, 12(39), 7673–7677. http://doi.org/10.1039/c4ob01604a | en_US |
| dc.identifier.uri | https://hdl.handle.net/1805/10755 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Royal Society of Chemistry | en_US |
| dc.relation.isversionof | 10.1039/c4ob01604a | en_US |
| dc.relation.journal | Organic & Biomolecular Chemistry | en_US |
| dc.rights | Publisher Policy | en_US |
| dc.source | PMC | en_US |
| dc.subject | Angiogenesis Inhibitors | en_US |
| dc.subject | Cell Proliferation | en_US |
| dc.subject | Human Umbilical Vein Endothelial Cells | en_US |
| dc.subject | Isoflavones | en_US |
| dc.title | The first synthesis of the antiangiogenic homoisoflavanone, cremastranone | en_US |
| dc.type | Article | en_US |