Elastic Properties of Polyunsaturated Phosphatidylethanolamines Influence Rhodopsin Function

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2013
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American English
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Royal Society of Chemistry
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Abstract

Membranes with a high content of polyunsaturated phosphatidylethanolamines (PE) facilitate formation of metarhodopsin-II (M(II)), the photointermediate of bovine rhodopsin that activates the G protein transducin. We determined whether M(II)-formation is quantitatively linked to the elastic properties of PEs. Curvature elasticity of monolayers of the polyunsaturated lipids 18 : 0-22 : 6(n - 3)PE, 18 : 0-22 : 5(n)- 6PE and the model lipid 18 : 1(n - 9)-18 : 1,(n- 9)PE were investigated in the inverse hexagonal phase. All three lipids form lipid monolayers with rather low spontaneous radii of curvature of 26-28 angstroms. In membranes, all three PEs generate high negative curvature elastic stress that shifts the equilibrium of MI(I)/M(II) photointermediates of rhodopsin towards M(II) formation.

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Teague WE Jr, Soubias O, Petrache H, et al. Elastic properties of polyunsaturated phosphatidylethanolamines influence rhodopsin function. Faraday Discuss. 2013;161:383-459. doi:10.1039/c2fd20095c
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Faraday Discussions
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PMC
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