Critical review of the Appropriate Use Criteria for amyloid imaging: Effect on diagnosis and patient care

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Date
2016-12-18
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American English
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Elsevier
Abstract

INTRODUCTION:

The utility of the Appropriate Use Criteria (AUC) for amyloid imaging is not established. METHODS:

Fifty-three cognitively impaired patients with clinical F18-florbetapir imaging were classified as early and late onset, as well as AUC-consistent or AUC-inconsistent. Chi-square statistics and t test were used to compare demographic characteristics and clinical outcomes as appropriate. RESULTS:

Early-onset patients were more likely to be amyloid positive. Change in diagnosis was more frequent in late-onset cases. Change in therapy was more common in early-onset cases. AUC-consistent and AUC-inconsistent cases had comparable rates of amyloid positivity. We saw no difference in the rate of treatment changes in the AUC-consistent group as opposed to the AUC-inconsistent group. DISCUSSION:

The primary role of amyloid imaging in the early-onset group was to confirm the clinically suspected etiology, and in the late-onset group in detecting amyloid-negative cases. The rate of therapeutic changes was significantly greater in the early-onset cases.

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Apostolova, L. G., Haider, J. M., Goukasian, N., Rabinovici, G. D., Chételat, G., Ringman, J. M., … Silverman, D. H. (2016). Critical review of the Appropriate Use Criteria for amyloid imaging: Effect on diagnosis and patient care. Alzheimer’s & Dementia : Diagnosis, Assessment & Disease Monitoring, 5, 15–22. http://doi.org/10.1016/j.dadm.2016.12.001
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Alzheimer’s & Dementia : Diagnosis, Assessment & Disease Monitoring
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PMC
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