CD4 T cells but not Th17 cells are Required for Mouse Lung Transplant Obliterative Bronchiolitis
dc.contributor.author | Wu, Qiang | |
dc.contributor.author | Gupta, Pawan Kumar | |
dc.contributor.author | Suzuki, Hidemi | |
dc.contributor.author | Wagner, Sarah R. | |
dc.contributor.author | Zhang, Chen | |
dc.contributor.author | Cummings, Oscar W. | |
dc.contributor.author | Fan, Lin | |
dc.contributor.author | Kaplan, Mark H. | |
dc.contributor.author | Wilkes, David S. | |
dc.contributor.author | Shilling, Rebecca A. | |
dc.contributor.department | Department of Pediatrics, Indiana University School of Medicine | en_US |
dc.date.accessioned | 2015-11-19T15:09:17Z | |
dc.date.available | 2015-11-19T15:09:17Z | |
dc.date.issued | 2015-07 | |
dc.description.abstract | Lung transplant survival is limited by obliterative bronchiolitis (OB), but the mechanisms of OB development are unknown. Previous studies in a mouse model of orthotopic lung transplantation suggested a requirement for IL-17. We have used this orthotopic mouse model to investigate the source of IL-17A and the requirement for T cells producing IL-17A. The major sources of IL-17A were CD4+ T cells and γδ T cells. Depletion of CD4+ T cells led to a significantly decreased frequency and number of IL-17A+ lymphocytes and was sufficient to prevent acute rejection and OB. However, mice with STAT3-deficient T cells, which are unable to differentiate into Th17 cells, rejected lung allografts and developed OB similar to control mice. The frequency of IL-17A+ cells was not decreased in mice with STAT3-deficient T cells due mainly to the presence of IL-17A+ γδ T cells. Deficiency of γδ T cells also did not affect the development of airway fibrosis. Our data suggest that CD4+ T cells are required for OB development and expansion of IL-17A responses in the lung, while Th17 and γδ T cells are not absolutely required and may compensate for each other. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Wu, Q., Gupta, P. K., Suzuki, H., Wagner, S. R., Zhang, C., Cummings, O. W., ... & Shilling, R. A. (2015). CD4 T Cells but Not Th17 Cells Are Required for Mouse Lung Transplant Obliterative Bronchiolitis. American Journal of Transplantation. http://dx.doi.org/10.1111/ajt.13215 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/7495 | |
dc.language.iso | en_US | en_US |
dc.publisher | Wiley | en_US |
dc.relation.isversionof | 10.1111/ajt.13215 | en_US |
dc.relation.journal | American Journal of Transplantation | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Author | en_US |
dc.subject | CD4 | en_US |
dc.subject | t-cells | en_US |
dc.subject | lung transplantation | en_US |
dc.title | CD4 T cells but not Th17 cells are Required for Mouse Lung Transplant Obliterative Bronchiolitis | en_US |
dc.type | Article | en_US |
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