Preservation of male fertility in patients undergoing pelvic irradiation

dc.contributor.authorRamirez-Fort, Marigdalia K.
dc.contributor.authorKardoust-Parizi, Mehdi
dc.contributor.authorFlannigan, Ryan
dc.contributor.authorBach, Phil
dc.contributor.authorKoch, Nicholas
dc.contributor.authorGilman, Casey
dc.contributor.authorSuarez, Paula
dc.contributor.authorFort, Digna V.
dc.contributor.authorMcClelland, Shearwood, III
dc.contributor.authorLange, Christopher S.
dc.contributor.authorMulhall, John P.
dc.contributor.authorFort, Migdalia
dc.contributor.authorSchlegel, Peter N.
dc.contributor.departmentRadiation Oncology, School of Medicine
dc.date.accessioned2024-06-26T12:06:03Z
dc.date.available2024-06-26T12:06:03Z
dc.date.issued2024-02-16
dc.description.abstractAs the number of cancer survivors increases, so does the demand for preserving male fertility after radiation. It is important for healthcare providers to understand the pathophysiology of radiation-induced testicular injury, the techniques of fertility preservation both before and during radiation, and their role in counseling patients on the risks to their fertility and the means of mitigating these risks. Impaired spermatogenesis is a known testicular toxicity of radiation in both the acute and the late settings, as rapidly dividing spermatogonial germ cells are exquisitely sensitive to irradiation. The threshold for spermatogonial injury and subsequent impairment in spermatogenesis is ~ 0.1 Gy and the severity of gonadal injury is highly dose-dependent. Total doses < 4 Gy may allow for recovery of spermatogenesis and fertility potential, but with larger doses, recovery may be protracted or impossible. All patients undergoing gonadotoxic radiation therapy should be counseled on the possibility of future infertility, offered the opportunity for semen cryopreservation, and offered referral to a fertility specialist. In addition to this, every effort should be made to shield the testes (if not expected to contain tumor) during therapy.
dc.eprint.versionFinal published version
dc.identifier.citationRamirez-Fort MK, Kardoust-Parizi M, Flannigan R, et al. Preservation of male fertility in patients undergoing pelvic irradiation. Rep Pract Oncol Radiother. 2024;28(6):835-845. Published 2024 Feb 16. doi:10.5603/rpor.98731
dc.identifier.urihttps://hdl.handle.net/1805/41902
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isversionof10.5603/rpor.98731
dc.relation.journalReports of Practical Oncology and Radiotherapy
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourcePMC
dc.subjectElectroejaculation
dc.subjectGonadotoxic radiation
dc.subjectMale fertility
dc.subjectPenile vibrostimulation
dc.subjectSemen cryopreservation
dc.titlePreservation of male fertility in patients undergoing pelvic irradiation
dc.typeArticle
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