Current state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panel

dc.contributor.authorSpurney, Christopher F.
dc.contributor.authorAscheim, Deborah
dc.contributor.authorCharnas, Lawrence
dc.contributor.authorCripe, Linda
dc.contributor.authorHor, Kan
dc.contributor.authorKing, Nicholas
dc.contributor.authorKinnett, Kathi
dc.contributor.authorMcNally, Elizabeth M.
dc.contributor.authorSauer, John-Michael
dc.contributor.authorSweeney, Lee
dc.contributor.authorVilla, Chet
dc.contributor.authorMarkham, Larry W.
dc.contributor.departmentPediatrics, School of Medicine
dc.date.accessioned2025-03-26T11:17:59Z
dc.date.available2025-03-26T11:17:59Z
dc.date.issued2021
dc.description.abstractCardiac disease is now the leading cause of death in Duchenne muscular dystrophy (DMD). Clinical evaluations over time have demonstrated asymptomatic cardiac troponin elevations and acute elevations are associated with symptoms and cardiac dysfunction in DMD. Clinicians require a better understanding of the relationship of symptoms, troponin levels and progression of cardiac disease in DMD. As clinical trials begin to assess novel cardiac therapeutics in DMD, troponin levels in DMD are important for safety monitoring and outcome measures. The Parent Project Muscular Dystrophy convened an expert panel of cardiologists, scientists, and regulatory and industry specialists on 16 December 2019 in Silver Spring, Maryland and reviewed published and unpublished data from their institutions. The panel recommended retrospective troponin data analyses, prospective longitudinal troponin collection using high-sensitivity cardiac troponin I assays, inclusion of troponin in future clinical trial outcomes and future development of clinical guidelines for monitoring and treating troponin elevations in DMD.
dc.eprint.versionFinal published version
dc.identifier.citationSpurney CF, Ascheim D, Charnas L, et al. Current state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panel. Open Heart. 2021;8(1):e001592. doi:10.1136/openhrt-2021-001592
dc.identifier.urihttps://hdl.handle.net/1805/46609
dc.language.isoen_US
dc.publisherBMJ
dc.relation.isversionof10.1136/openhrt-2021-001592
dc.relation.journalOpen Heart
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourcePMC
dc.subjectBiomarkers
dc.subjectGenetic diseases
dc.subjectInborn
dc.subjectCardiomyopathy
dc.subjectDilated
dc.titleCurrent state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panel
dc.typeArticle
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