Genome-wide association study of serum iron phenotypes in premenopausal women of European descent

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2016-03
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American English
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Elsevier
Abstract

A genome-wide association study was performed in 1,130 premenopausal women to detect common variants associated with three serum iron-related phenotypes. Total iron binding capacity was strongly associated (p=10−14) with variants in and near the TF gene (transferrin), the serum iron transporting protein, and with variants in HFE (p= 4×10−7), which encodes the human hemochromatosis gene. Association was also detected between percent iron saturation (p=10−8) and variants in the chromosome 6 region containing both HFE and SLC17A2, which encodes a phosphate transport protein. No significant associations were detected with serum iron, but variants in HFE were suggestive (p=10−6). Our results corroborate prior studies in older subjects and demonstrate that the association of these genetic variants with iron phenotypes can be detected in premenopausal women.

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Koller, D. L., Imel, E. A., Lai, D., Padgett, L. R., Acton, D., Gray, A., … Foroud, T. (2016). Genome-wide association study of serum iron phenotypes in premenopausal women of European descent. Blood Cells, Molecules & Diseases, 57, 50–53. http://doi.org/10.1016/j.bcmd.2015.12.002
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Blood Cells, Molecules & Diseases
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