STAT4 is required for IL-23 responsiveness in Th17 memory cells and NKT cells
dc.contributor.author | Glosson-Byers, Nicole L. | |
dc.contributor.author | Sehra, Sarita | |
dc.contributor.author | Kaplan, Mark H. | |
dc.contributor.department | Department of Pediatrics, School of Medicine | en_US |
dc.date.accessioned | 2016-10-07T14:40:02Z | |
dc.date.available | 2016-10-07T14:40:02Z | |
dc.date.issued | 2014-10-30 | |
dc.description.abstract | STAT4 is a critical mediator of inflammatory immunity and is required for all known IL-12 biological responses, including the induction of IFN-γ and development of Th1 cells. We demonstrate that IL-23, an IL-12-related cytokine, also requires STAT4 for optimal IL-17 secretion from memory T helper cells and NKT cells. Although IL-23 stimulation had modest effects on STAT4 activation, STAT4-deficiency results in reduced Il23r expression. These data demonstrate a restricted requirement for STAT4 in innate and adaptive IL-17-secreting T cell responses that might contribute to inflammatory immunity. | en_US |
dc.identifier.citation | Glosson-Byers, N. L., Sehra, S., & Kaplan, M. H. (2014). STAT4 is required for IL-23 responsiveness in Th17 memory cells and NKT cells. JAK-STAT, 3(3), e955393. http://doi.org/10.4161/21623988.2014.955393 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/11138 | |
dc.language.iso | en_US | en_US |
dc.publisher | Taylor & Francis Group | en_US |
dc.relation.isversionof | 10.4161/21623988.2014.955393 | en_US |
dc.relation.journal | JAK-STAT | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | IL-23R | en_US |
dc.subject | memory Th | en_US |
dc.subject | NKT | en_US |
dc.subject | STAT4 | en_US |
dc.subject | Th17 | en_US |
dc.title | STAT4 is required for IL-23 responsiveness in Th17 memory cells and NKT cells | en_US |
dc.type | Article | en_US |
ul.alternative.fulltext | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580079/ | en_US |
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