Implication of the emergence of the delta (B.1.617.2) variants on vaccine effectiveness

dc.contributor.authorAl‑Tawfiq, Jaffar A.
dc.contributor.authorKoritala, Thoyaja
dc.contributor.authorAlhumaid, Saad
dc.contributor.authorBarry, Mazin
dc.contributor.authorAlshukairi, Abeer N.
dc.contributor.authorTemsah, Mohamad‑Hani
dc.contributor.authorAl Mutair, Abbas
dc.contributor.authorRabaan, Ali
dc.contributor.authorTirupathi, Raghavendra
dc.contributor.authorGautret, Philippe
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2023-05-12T17:29:45Z
dc.date.available2023-05-12T17:29:45Z
dc.date.issued2022-06
dc.description.abstractIntroduction: COVID-19 vaccines have been developed to compact the current SARS-CoV-2 pandemic and have been administered to people all over the world. These vaccines have been quite effective in reducing the possibility of severe illness, hospitalization and death. However, the recent emergence of Variants of Concern specifically the delta variant, B.1.617.2, had resulted in additional waves of the pandemic. Methods: We aim to review the literature to understand the transmission and disease severity, and determine the efficacy of the current COVID-19 vaccines. We searched Pubmed, Scopus, and Embase till August 4th 2021, and used the search terms "delta variant", "vaccinations"," breakthrough infections", and "neutralizing antibody". For the meta-analysis, 21 studies were screened in particular and five articles (148,071 cases) were included in the study, and only four were analyzed in the meta-analysis. Results: In this review, both in vitro and in vivo studies showed significant reductions in neutralization rates against delta variants for vaccinated individuals and convalescent patients with prior history of COVID-19. However, There was a lower incidence of infection with SARS-CoV-2 due to Delta variant was found after the second dose of Pfizer-BioNTech, Oxford-AstraZeneca and Moderna vaccines. Conclusion: In fully vaccinated individuals, symptomatic infection with the delta variant was significantly reduced, and therefore, vaccinations play an important role to assist the fight against delta variant.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationAl-Tawfiq JA, Koritala T, Alhumaid S, et al. Implication of the emergence of the delta (B.1.617.2) variants on vaccine effectiveness. Infection. 2022;50(3):583-596. doi:10.1007/s15010-022-01759-1en_US
dc.identifier.urihttps://hdl.handle.net/1805/32949
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s15010-022-01759-1en_US
dc.relation.journalInfectionen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectCOVID-19en_US
dc.subjectDelta varianten_US
dc.subjectSARS-CoV-2en_US
dc.subjectVariantsen_US
dc.titleImplication of the emergence of the delta (B.1.617.2) variants on vaccine effectivenessen_US
dc.typeArticleen_US
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811010/en_US
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