The Need for Pediatric Formulations to Treat Children with HIV

Simple item page
dc.contributor.authorSchlatter, Adrienne F.
dc.contributor.authorDeathe, Andrew R.
dc.contributor.authorVreeman, Rachel C.
dc.contributor.departmentDepartment of Pediatrics, IU School of Medicineen_US
dc.date.accessioned2017-05-19T16:45:57Z
dc.date.available2017-05-19T16:45:57Z
dc.date.issued2016
dc.description.abstractOver 3.2 million children worldwide are infected with HIV, but only 24% of these children receive antiretroviral therapy (ART). ART adherence among children is a crucial part of managing human-immunodeficiency virus (HIV) infection and extending the life and health of infected children. Important causes of poor adherence are formulation- and regimen-specific properties, including poor palatability, large pill burden, short dosing intervals, and the complex storage and transportation of drugs. This review aims to summarize the various regimen- and formulation-based barriers to ART adherence among children to support the need for new and innovative pediatric formulations for antiretroviral therapy (ART). Detailing the arguments both for and against investing in the development of pediatric HIV medications, as well as highlighting recent advances in pediatric ART formulation research, provides a synopsis of the current data related to pediatric ART formulations and adherence.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationSchlatter, A. F., Deathe, A. R., & Vreeman, R. C. (2016). The Need for Pediatric Formulations to Treat Children with HIV. AIDS Research and Treatment, 2016, 1654938. http://doi.org/10.1155/2016/1654938en_US
dc.identifier.issn2090-1240en_US
dc.identifier.urihttps://hdl.handle.net/1805/12630
dc.language.isoen_USen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.isversionof10.1155/2016/1654938en_US
dc.relation.journalAIDS research and treatmenten_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/
dc.sourcePMCen_US
dc.subjectHIVen_US
dc.subjectHuman Immunodeficiency Virusen_US
dc.subjectAntiretroviral Therapy, Highly Activeen_US
dc.subjectAnti-HIV Agentsen_US
dc.subjectadministration & dosageen_US
dc.subjectChild Healthen_US
dc.titleThe Need for Pediatric Formulations to Treat Children with HIVen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ART2016-1654938.pdf
Size:
538.95 KB
Format:
Adobe Portable Document Format
Description:
Final published version
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.88 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Access Policy Articles
Department of Pediatrics Works