Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids

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dc.contributor.authorSundaram, Suneha
dc.contributor.authorVuppalanchi, Raj
dc.contributor.authorSaxena, Romil
dc.contributor.authorChalasani, Naga
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2020-06-24T13:30:01Z
dc.date.available2020-06-24T13:30:01Z
dc.date.issued2020-02
dc.description.abstractIdiosyncratic drug-induced liver injury (DILI), when severe, can be associated with significant morbidity and mortality. Currently, there are no specific therapies for DILI, apart from corticosteroids for drug-induced autoimmune hepatitis caused by drugs such as nitrofurantoin or minocycline. We present 2 cases of DILI that improved with corticosteroid therapy despite the lack of autoimmune features by serology or histology. The current observations make a strong case for formally testing corticosteroids in a controlled trial in patients with suspected DILI.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationSundaram, S., Vuppalanchi, R., Saxena, R., & Chalasani, N. (2020). Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids. ACG case reports journal, 7(2), e00319. https://doi.org/10.14309/crj.0000000000000319en_US
dc.identifier.urihttps://hdl.handle.net/1805/23065
dc.language.isoen_USen_US
dc.publisherAmerican College of Gastroenterologyen_US
dc.relation.isversionof10.14309/crj.0000000000000319en_US
dc.relation.journalACG Case Reports Journalen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0*
dc.sourcePMCen_US
dc.subjectDrug-induced liver injuryen_US
dc.subjectMorbidityen_US
dc.subjectMortalityen_US
dc.subjectCorticosteroid therapyen_US
dc.subjectControlled patient trialsen_US
dc.titleTreatment of Idiosyncratic Drug-Induced Liver Injury Using Steroidsen_US
dc.typeArticleen_US
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