Trends in the Management Paradigms of Intracranial Meningioma

dc.contributor.authorAljuboori, Zaid
dc.contributor.authorAlhourani, Ahmad
dc.contributor.authorWoo, Shiao
dc.contributor.authorHattab, Eyas
dc.contributor.authorYusuf, Mehran
dc.contributor.authorNelson, Megan
dc.contributor.authorAndaluz, Norberto
dc.contributor.authorDing, Dale
dc.contributor.authorSavage, Jesse
dc.contributor.authorWilliams, Brian
dc.contributor.departmentNeurological Surgery, School of Medicineen_US
dc.date.accessioned2023-06-14T14:48:55Z
dc.date.available2023-06-14T14:48:55Z
dc.date.issued2021
dc.description.abstractObjective: Intracranial meningiomas are the most common primary brain tumor. Treatment paradigms have evolved over time. There are limited number of population-based studies that examine this modern evolution. Here, we describe the trends of management of intracranial meningiomas using a national database. Methods: The data were obtained from the National Cancer Database for the years 2004 to 2015, the collected variables included: patients' age, gender, insurance type, income, comorbidity score, the tumor size and grade, and treatment modality (observation, surgery, radiotherapy, or combination therapy). We performed statistical analyses to detect association between unique variables and outcomes. In addition, we performed mortality analyses for various treatment modalities. Results: A total of 199,096 patients with a diagnosis of intracranial meningioma were included, the majority of patients were white females, mean age of 61 years, and half of the tumors were ≤ 3 cm. Observation was the most commonly used management modality followed by surgical resection, radiotherapy, and combination therapy. For the entire time period, there was an increased use of observation as a primary management method. Predictors of mortality included increased age, larger tumor size, higher tumor grade, treatment at a community hospital, and higher comorbidity scores. Conclusion: Population-based studies of intracranial meningiomas are uncommon; our study is one of the few reports that examine the changes in the modern management paradigms of meningioma in the United States over time. Additionally, we shed light on the factors that affected survival of patients with this condition.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationAljuboori Z, Alhourani A, Woo S, et al. Trends in the Management Paradigms of Intracranial Meningioma. J Neurol Surg B Skull Base. 2021;82(2):208-215. doi:10.1055/s-0039-1697036en_US
dc.identifier.urihttps://hdl.handle.net/1805/33755
dc.language.isoen_USen_US
dc.publisherThiemeen_US
dc.relation.isversionof10.1055/s-0039-1697036en_US
dc.relation.journalJournal of Neurological Surgery Part B: Skull Baseen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectBrain tumoren_US
dc.subjectMeningiomaen_US
dc.subjectSurgeryen_US
dc.subjectRadiotherapyen_US
dc.subjectObservationen_US
dc.subjectDatabaseen_US
dc.titleTrends in the Management Paradigms of Intracranial Meningiomaen_US
dc.typeArticleen_US
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987396/en_US
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