Field-Switching Repeller Flowing Atmospheric-Pressure Afterglow Drift Tube Ion Mobility Spectrometry
dc.contributor.author | Latif, Mohsen | |
dc.contributor.author | Chen, Xi | |
dc.contributor.author | Gandhi, Viraj D. | |
dc.contributor.author | Larriba-Andaluz, Carlos | |
dc.contributor.author | Gamez, Gerardo | |
dc.contributor.department | Mechanical and Energy Engineering, School of Engineering and Technology | |
dc.date.accessioned | 2023-12-15T21:37:36Z | |
dc.date.available | 2023-12-15T21:37:36Z | |
dc.date.issued | 2022-03-02 | |
dc.description.abstract | In this work, a field-switching (FS) technique is employed with a flowing atmospheric pressure afterglow (FAPA) source in drift tube ion mobility spectrometry (DTIMS). The premise is to incorporate a tip-repeller electrode as a substitute for the Bradbury–Nielsen gate (BNG) so as to overcome corresponding disadvantages of the BNG, including the gate depletion effect (GDE). The DTIMS spectra were optimized in terms of peak shape and full width by inserting an aperture at the DTIMS inlet that was used to control the neutral molecules’ penetration into the separation region, thus preventing neutral-ion reactions inside. The FAPA and repeller’s experimental operating conditions including drift and plasma gas flow rates, pulse injection times, repeller positioning and voltage, FAPA current, and effluent angle were optimized. Ion mobility spectra of selected compounds were captured, and the corresponding reduced mobility values were calculated and compared with the literature. The 6-fold improvements in limit of detection (LOD) compared with previous work were obtained for 2,6-DTBP and acetaminophen. The enhanced performance of the FS-FAPA-DTIMS was also investigated as a function of the GDE when compared with FAPA-DTIMS containing BNG. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Latif, M., Chen, X., Gandhi, V. D., Larriba-Andaluz, C., & Gamez, G. (2022). Field-Switching Repeller Flowing Atmospheric-Pressure Afterglow Drift Tube Ion Mobility Spectrometry. Journal of the American Society for Mass Spectrometry, 33(4), 635–648. https://doi.org/10.1021/jasms.1c00309 | |
dc.identifier.uri | https://hdl.handle.net/1805/37393 | |
dc.language.iso | en_US | |
dc.publisher | American Chemical Society | |
dc.relation.isversionof | 10.1021/jasms.1c00309 | |
dc.relation.journal | Journal of the American Society for Mass Spectrometry | |
dc.rights | Publisher Policy | |
dc.source | Author | |
dc.subject | drift tube ion mobility spectrometry | |
dc.subject | field-switching technique | |
dc.subject | flowing atmospheric-pressure afterglow | |
dc.subject | gate depletion effect | |
dc.subject | ambient desorption/ionization | |
dc.subject | Bradbury−Nielsen | |
dc.title | Field-Switching Repeller Flowing Atmospheric-Pressure Afterglow Drift Tube Ion Mobility Spectrometry | |
dc.type | Article |