Magnetic-field-synchronized wireless modulation of neural activity by magnetoelectric nanoparticles
dc.contributor.author | Zhang, E. | |
dc.contributor.author | Abdel-Mottaleb, M. | |
dc.contributor.author | Liang, P. | |
dc.contributor.author | Navarrete, B. | |
dc.contributor.author | Akin Yildirim, Y. | |
dc.contributor.author | Alberteris Campos, M. | |
dc.contributor.author | Smith, I. T. | |
dc.contributor.author | Wang, P. | |
dc.contributor.author | Yildirim, B. | |
dc.contributor.author | Yang, L. | |
dc.contributor.author | Chen, S. | |
dc.contributor.author | Smith, I. | |
dc.contributor.author | Lur, G. | |
dc.contributor.author | Nguyen, T. | |
dc.contributor.author | Jin, X. | |
dc.contributor.author | Noga, B. R. | |
dc.contributor.author | Ganzer, P. | |
dc.contributor.author | Khizroev, S. | |
dc.contributor.department | Anesthesia, School of Medicine | |
dc.date.accessioned | 2024-06-07T11:48:56Z | |
dc.date.available | 2024-06-07T11:48:56Z | |
dc.date.issued | 2022 | |
dc.description.abstract | The in vitro study demonstrates wirelessly controlled modulation of neural activity using magnetoelectric nanoparticles (MENPs), synchronized to magnetic field application with a sub-25-msec temporal response. Herein, MENPs are sub-30-nm CoFe2O4@BaTiO3 core-shell nanostructures. MENPs were added to E18 rat hippocampal cell cultures (0.5 μg of MENPs per 100,000 neurons) tagged with fluorescent Ca2+ sensitive indicator cal520. MENPs were shown to wirelessly induce calcium transients which were synchronized with application of 1200-Oe bipolar 25-msec magnetic pulses at a rate of 20 pulses/sec. The observed calcium transients were similar, in shape and magnitude, to those generated through the control electric field stimulation with a 50-μA current, and they were inhibited by the sodium channel blocker tetrodotoxin. The observed MENP-based magnetic excitation of neural activity is in agreement with the non-linear M - H hysteresis loop of the MENPs, wherein the MENPs' coercivity value sets the threshold for the externally applied magnetic field. | |
dc.eprint.version | Final published version | |
dc.identifier.citation | Zhang E, Abdel-Mottaleb M, Liang P, et al. Magnetic-field-synchronized wireless modulation of neural activity by magnetoelectric nanoparticles [published correction appears in Brain Stimul. 2023 Jul-Aug;16(4):981]. Brain Stimul. 2022;15(6):1451-1462. doi:10.1016/j.brs.2022.10.004 | |
dc.identifier.uri | https://hdl.handle.net/1805/41287 | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | |
dc.relation.isversionof | 10.1016/j.brs.2022.10.004 | |
dc.relation.journal | Brain Stimulation | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.source | Publisher | |
dc.subject | Calcium | |
dc.subject | Magnetic fields | |
dc.subject | Nanoparticles | |
dc.subject | Neurons | |
dc.title | Magnetic-field-synchronized wireless modulation of neural activity by magnetoelectric nanoparticles | |
dc.type | Article |