Advances in uromodulin biology and potential clinical applications

dc.contributor.authorNanamatsu, Azuma
dc.contributor.authorde Araújo, Larissa
dc.contributor.authorLaFavers, Kaice A.
dc.contributor.authorEl-Achkar, Tarek M.
dc.contributor.departmentMedicine, School of Medicine
dc.date.accessioned2025-07-16T13:39:42Z
dc.date.available2025-07-16T13:39:42Z
dc.date.issued2024
dc.description.abstractUromodulin (also known as Tamm-Horsfall protein) is a kidney-specific glycoprotein secreted bidirectionally into urine and into the circulation, and it is the most abundant protein in normal urine. Although the discovery of uromodulin predates modern medicine, its significance in health and disease has been rather enigmatic. Research studies have gradually revealed that uromodulin exists in multiple forms and has important roles in urinary and systemic homeostasis. Most uromodulin in urine is polymerized into highly organized filaments, whereas non-polymeric uromodulin is detected both in urine and in the circulation, and can have distinct roles. The interactions of uromodulin with the immune system, which were initially reported to be a key role of this protein, are now better understood. Moreover, the discovery that uromodulin is associated with a spectrum of kidney diseases, including acute kidney injury, chronic kidney disease and autosomal-dominant tubulointerstitial kidney disease, has further accelerated investigations into the role of this protein. These discoveries have prompted new questions and ushered in a new era in uromodulin research. Here, we delineate the latest discoveries in uromodulin biology and its emerging roles in modulating kidney and systemic diseases, and consider future directions, including its potential clinical applications.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationNanamatsu A, de Araújo L, LaFavers KA, El-Achkar TM. Advances in uromodulin biology and potential clinical applications. Nat Rev Nephrol. 2024;20(12):806-821. doi:10.1038/s41581-024-00881-7
dc.identifier.urihttps://hdl.handle.net/1805/49519
dc.language.isoen_US
dc.publisherSpringer Nature
dc.relation.isversionof10.1038/s41581-024-00881-7
dc.relation.journalNature Reviews: Nephrology
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectKidney diseases
dc.subjectUromodulin
dc.subjectHumans
dc.titleAdvances in uromodulin biology and potential clinical applications
dc.typeArticle
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