Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

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dc.contributor.authorMcDowell, Colleen M.
dc.contributor.authorKizhatil, Krishnakumar
dc.contributor.authorElliott, Michael H.
dc.contributor.authorOverby, Darryl R.
dc.contributor.authorVan Batenburg-Sherwood, Joseph
dc.contributor.authorMillar, J. Cameron
dc.contributor.authorKuehn, Markus H.
dc.contributor.authorZode, Gulab
dc.contributor.authorAcott, Ted S.
dc.contributor.authorAnderson, Michael G.
dc.contributor.authorBhattacharya, Sanjoy K.
dc.contributor.authorBertrand, Jacques A.
dc.contributor.authorBorras, Terete
dc.contributor.authorBovenkamp, Diane E.
dc.contributor.authorCheng, Lin
dc.contributor.authorDanias, John
dc.contributor.authorDe Ieso, Michael Lucio
dc.contributor.authorDu, Yiqin
dc.contributor.authorFaralli, Jennifer A.
dc.contributor.authorFuchshofer, Rudolf
dc.contributor.authorGanapathy, Preethi S.
dc.contributor.authorGong, Haiyan
dc.contributor.authorHerberg, Samuel
dc.contributor.authorHernandez, Humberto
dc.contributor.authorHumphries, Peter
dc.contributor.authorJohn, Simon W. M.
dc.contributor.authorKaufman, Paul L.
dc.contributor.authorKeller, Kate E.
dc.contributor.authorKelley, Mary J.
dc.contributor.authorKelly, Ruth A.
dc.contributor.authorKrizaj, David
dc.contributor.authorKumar, Ajay
dc.contributor.authorLeonard, Brian C.
dc.contributor.authorLieberman, Raquel L.
dc.contributor.authorLiton, Paloma
dc.contributor.authorLiu, Yutao
dc.contributor.authorLiu, Katy C.
dc.contributor.authorLopez, Navita N.
dc.contributor.authorMao, Weiming
dc.contributor.authorMavlyutov, Timur
dc.contributor.authorMcDonnell, Fiona
dc.contributor.authorMcLellan, Gillian J.
dc.contributor.authorMzyk, Philip
dc.contributor.authorNartey, Andrews
dc.contributor.authorPasquale, Louis R.
dc.contributor.authorPatel, Gaurang C.
dc.contributor.authorPattabiraman, Padmanabhan P.
dc.contributor.authorPeters, Donna M.
dc.contributor.authorRaghunathan, Vijaykrishna
dc.contributor.authorRao, Ponugoti Vasantha
dc.contributor.authorRayana, Naga
dc.contributor.authorRaychaudhuri, Urmimala
dc.contributor.authorReina-Torres, Ester
dc.contributor.authorRen, Ruiyi
dc.contributor.authorRhee, Douglas
dc.contributor.authorChowdhury, Uttio Roy
dc.contributor.authorSamples, John R.
dc.contributor.authorSamples, E. Griffen
dc.contributor.authorSharif, Najam
dc.contributor.authorSchuman, Joel S.
dc.contributor.authorSheffield, Val C.
dc.contributor.authorStevenson, Cooper H.
dc.contributor.authorSoundararajan, Avinash
dc.contributor.authorSubramanian, Preeti
dc.contributor.authorSugali, Chenna Kesavulu
dc.contributor.authorSun, Yang
dc.contributor.authorToris, Carol B.
dc.contributor.authorTorrejon, Karen Y.
dc.contributor.authorVahabikashi, Amir
dc.contributor.authorVranka, Janice A.
dc.contributor.authorWang, Ting
dc.contributor.authorWilloughby, Colin E.
dc.contributor.authorXin, Chen
dc.contributor.authorYun, Hongmin
dc.contributor.authorZhang, Hao F.
dc.contributor.authorFautsch, Michael P.
dc.contributor.authorTamm, Ernst R.
dc.contributor.authorClark, Abbot F.
dc.contributor.authorEthier, C. Ross
dc.contributor.authorStamer, W. Daniel
dc.contributor.departmentOphthalmology, School of Medicineen_US
dc.date.accessioned2023-07-12T19:20:53Z
dc.date.available2023-07-12T19:20:53Z
dc.date.issued2022-02
dc.description.abstractDue to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationMcDowell, C. M., Kizhatil, K., Elliott, M. H., Overby, D. R., van Batenburg-Sherwood, J., Millar, J. C., Kuehn, M. H., Zode, G., Acott, T. S., Anderson, M. G., Bhattacharya, S. K., Bertrand, J. A., Borras, T., Bovenkamp, D. E., Cheng, L., Danias, J., De Ieso, M. L., Du, Y., Faralli, J. A., … Stamer, W. D. (2022). Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Investigative Ophthalmology & Visual Science, 63(2), 12. https://doi.org/10.1167/iovs.63.2.12en_US
dc.identifier.urihttps://hdl.handle.net/1805/34331
dc.language.isoenen_US
dc.publisherARVOen_US
dc.relation.isversionof10.1167/iovs.63.2.12en_US
dc.relation.journalInvestigative Ophthalmology & Visual Scienceen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourcePublisheren_US
dc.subjectmouse modelen_US
dc.subjectconventional outflowen_US
dc.subjectglaucomaen_US
dc.titleConsensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanismsen_US
dc.typeArticleen_US
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