Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon

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dc.contributor.authorDirks, Rachel C.
dc.contributor.authorRichard, Jeffrey S.
dc.contributor.authorFearon, Angela M.
dc.contributor.authorScott, Alexander
dc.contributor.authorKoch, Lauren G.
dc.contributor.authorBritton, Steven L.
dc.contributor.authorWarden, Stuart J.
dc.contributor.departmentAnatomy, Cell Biology and Physiology, School of Medicine
dc.date.accessioned2025-05-20T13:38:30Z
dc.date.available2025-05-20T13:38:30Z
dc.date.issued2013-03-11
dc.description.abstractBackground: The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans. Methods: Twenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15° incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis. Results: There were no significant group differences within each of the individual histopathological categories assessed (all p ≥ 0.16) or for total histopathological score (p = 0.14). Conclusions: Uphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans.
dc.eprint.versionFinal published version
dc.identifier.citationDirks RC, Richard JS, Fearon AM, et al. Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon. BMC Musculoskelet Disord. 2013;14:90. Published 2013 Mar 11. doi:10.1186/1471-2474-14-90
dc.identifier.urihttps://hdl.handle.net/1805/48283
dc.language.isoen_US
dc.publisherSpringer Nature
dc.relation.isversionof10.1186/1471-2474-14-90
dc.relation.journalBMC Musculoskeletal Disorders
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePMC
dc.subjectAnimal model
dc.subjectTendinitis
dc.subjectTendinopathy
dc.subjectTendinosis
dc.subjectOveruse
dc.titleUphill treadmill running does not induce histopathological changes in the rat Achilles tendon
dc.typeArticle
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