Intake of methyl-related nutrients and risk of pancreatic cancer in a population-based case-control study in Minnesota
dc.contributor.author | Marley, Andrew R. | |
dc.contributor.author | Fan, Hao | |
dc.contributor.author | Hoyt, Margaret L. | |
dc.contributor.author | Anderson, Kristin E. | |
dc.contributor.author | Zhang, Jianjun | |
dc.contributor.department | Epidemiology, School of Public Health | en_US |
dc.date.accessioned | 2019-05-23T18:14:08Z | |
dc.date.available | 2019-05-23T18:14:08Z | |
dc.date.issued | 2018-08 | |
dc.description.abstract | BACKGROUND/OBJECTIVES: Folate, vitamin B6, vitamin B12, and methionine are involved in DNA synthesis and methylation and thus may modulate pancreatic cancer risk. We investigated these associations in a population-based case-control study conducted in 1994-1998. SUBJECTS/METHODS: Cases (n = 150) were identified from all hospitals in the metropolitan areas of the Twin Cities and the Mayo Clinic, Minnesota. Controls (n = 459) were selected randomly from the general population and were frequency matched to cases by age, sex, and race. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for risk of pancreatic cancer in relation to intake of nutrients considered. RESULTS: Dietary intake of folate was associated with a reduced pancreatic cancer risk [OR (95% CI) for quartile (Q) 4 vs. Q1: 0.31 (0.12-0.78)]. A composite score (range from 2 to 8), reflecting combined dietary intake of folate and vitamin B6, was also inversely associated with pancreatic cancer risk [OR (95% CI) for Q4 vs. Q1: 0.24 (0.08-0.70)]. Null associations were found for intake of vitamin B12 and methionine. CONCLUSIONS: Dietary folate intake was associated with a reduced pancreatic cancer risk, and this association became stronger when dietary intake of folate and vitamin B6 was combined in analysis. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Marley, A. R., Fan, H., Hoyt, M. L., Anderson, K. E., & Zhang, J. (2018). Intake of methyl-related nutrients and risk of pancreatic cancer in a population-based case-control study in Minnesota. European journal of clinical nutrition, 72(8), 1128–1135. doi:10.1038/s41430-018-0228-5 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/19444 | |
dc.language.iso | en_US | en_US |
dc.publisher | Springer Nature | en_US |
dc.relation.isversionof | 10.1038/s41430-018-0228-5 | en_US |
dc.relation.journal | European Journal of Clinical Nutrition | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | DNA methylation | en_US |
dc.subject | Dietary supplements | en_US |
dc.subject | Folic acid | en_US |
dc.subject | Methionine | en_US |
dc.subject | Pancreatic neoplasms | en_US |
dc.subject | Vitamin B 12 | en_US |
dc.subject | Vitamin B 6 | en_US |
dc.title | Intake of methyl-related nutrients and risk of pancreatic cancer in a population-based case-control study in Minnesota | en_US |
dc.type | Article | en_US |