Genetic Testing for Parkinson Disease: Are We Ready?

dc.contributor.authorCook, Lola
dc.contributor.authorSchulze, Jeanine
dc.contributor.authorKopil, Catherine
dc.contributor.authorHastings, Tara
dc.contributor.authorNaito, Anna
dc.contributor.authorWojcieszek, Joanne
dc.contributor.authorPayne, Katelyn
dc.contributor.authorAlcalay, Roy N.
dc.contributor.authorKlein, Christine
dc.contributor.authorSaunders-Pullman, Rachel
dc.contributor.authorSimuni, Tatyana
dc.contributor.authorForoud, Tatiana
dc.contributor.departmentMedical and Molecular Genetics, School of Medicineen_US
dc.date.accessioned2023-05-10T13:44:14Z
dc.date.available2023-05-10T13:44:14Z
dc.date.issued2021-02
dc.description.abstractPurpose of review: With the advent of precision medicine and demand for genomic testing information, we may question whether it is time to offer genetic testing to our patients with Parkinson disease (PD). This review updates the current genetic landscape of PD, describes what genetic testing may offer, provides strategies for evaluating whom to test, and provides resources for the busy clinician. Recent findings: Patients with PD and their relatives, in various settings, have expressed an interest in learning their PD genetic status; however, physicians may be hesitant to widely offer testing due to the perceived low clinical utility of PD genetic test results. The rise of clinical trials available for patients with gene-specific PD and emerging information on genotype-phenotype correlations are starting to shift this discussion about testing. Summary: By learning more about the various genetic testing options for PD and utility of results for patients and their care, clinicians may become more comfortable with widespread PD genetic testing in the research and clinical setting.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationCook L, Schulze J, Kopil C, et al. Genetic Testing for Parkinson Disease: Are We Ready?. Neurol Clin Pract. 2021;11(1):69-77. doi:10.1212/CPJ.0000000000000831en_US
dc.identifier.urihttps://hdl.handle.net/1805/32896
dc.language.isoen_USen_US
dc.publisherAmerican Academy of Neurologyen_US
dc.relation.isversionof10.1212/CPJ.0000000000000831en_US
dc.relation.journalNeurology: Clinical Practiceen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectPrecision medicineen_US
dc.subjectGenomic testingen_US
dc.subjectGenetic testingen_US
dc.subjectParkinson diseaseen_US
dc.titleGenetic Testing for Parkinson Disease: Are We Ready?en_US
dc.typeArticleen_US
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101316/en_US
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