The impact of obesity in patients hospitalized with opioid/opiate overdose
dc.contributor.author | Archibald, Paul | |
dc.contributor.author | Subramoney, Kavitha | |
dc.contributor.author | Beydoun, Hind A. | |
dc.contributor.author | Harris, Ché Matthew | |
dc.contributor.department | Medicine, School of Medicine | |
dc.date.accessioned | 2024-04-01T15:35:01Z | |
dc.date.available | 2024-04-01T15:35:01Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Background: Although a direct link between opioid use in obese patients and risk of overdose has not been established, obesity is highly associated with higher risk for opioid/opiate overdose. Evidence for clinical impact of obesity on patients with opioid/opiate overdose is scarce. The aim of this study was to determine effects of obesity on health-care outcomes and mortality trends in hospitalized patients who presented with opioid/opiate overdose in the United States between 2010 and 2014. Design: Multivariate logistic and linear regression analysis compared clinical outcomes and hospital resource utilization between obese and nonobese patients. Trend analysis of in-hospital mortality was also analyzed. Setting: United States. Participants: 302,863 adults ≥ 18 years and hospitalized with a principle diagnosis of opioid/opiate overdoses between 2010 and 2014. Measurements: Primary measurement was in-hospital mortality. Secondary measurements included respiratory failure, cardiogenic shock, mechanical ventilations/intubations, hospital charges, and length of stay. Findings: Prevalence for in-hospital mortality was lower in patients with obesity (2.2% vs 2.9%). Obese patients had higher adjusted odds for respiratory failure (aOR = 1.7, [(CI) 1.6-1.8]) and mechanical ventilation/intubation (aOR = 1.17, [(CI) 1.10-1.2]). They also had longer length of stays (aMD = 0.4 days, [(CI) 0.25-0.58 days] and higher total hospital charges (aMD = $5,561, [(CI) $3,638-$7,483]. Trends of in-hospital mortality for patients with obesity did not significantly increase (2.1% in 2010 to 2.4% in 2014, p trend = 0.37), but significantly increased for obese patients (2.4% in 2010 to 3.4% in 2014; p trend <0.01). Conclusions: Prevalence and trends of mortality were lower in patients with obesity hospitalized for opiate/opioid overdose compared to those without obesity between 2010 and 2014 in the United States. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Archibald P, Subramoney K, Beydoun HA, Harris CM. The impact of obesity in patients hospitalized with opioid/opiate overdose. Subst Abus. 2022;43(1):253-259. doi:10.1080/08897077.2021.1941505 | |
dc.identifier.uri | https://hdl.handle.net/1805/39656 | |
dc.language.iso | en_US | |
dc.publisher | Sage | |
dc.relation.isversionof | 10.1080/08897077.2021.1941505 | |
dc.relation.journal | Substance Use & Addiction Journal | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Opioid overdose | |
dc.subject | Opiate overdose | |
dc.subject | Obesity | |
dc.subject | Large database | |
dc.subject | Hospitalizations | |
dc.subject | Hospital mortality | |
dc.subject | United States | |
dc.title | The impact of obesity in patients hospitalized with opioid/opiate overdose | |
dc.type | Article |