Weaning of Moderately Preterm Infants from the Incubator to the Crib: A Randomized Clinical Trial
dc.contributor.author | Shankaran, Seetha | |
dc.contributor.author | Bell, Edward F. | |
dc.contributor.author | Laptook, Abbot R. | |
dc.contributor.author | Saha, Shampa | |
dc.contributor.author | Newman, Nancy S. | |
dc.contributor.author | Kazzi, S. Nadya J. | |
dc.contributor.author | Barks, John | |
dc.contributor.author | Stoll, Barbara J. | |
dc.contributor.author | Bara, Rebecca | |
dc.contributor.author | Gabrio, Jenna | |
dc.contributor.author | Childs, Kirsten | |
dc.contributor.author | Das, Abhik | |
dc.contributor.author | Higgins, Rosemary D. | |
dc.contributor.author | Carlo, Waldemar A. | |
dc.contributor.author | Sánchez, Pablo J. | |
dc.contributor.author | Carlton, David P. | |
dc.contributor.author | Pavageau, Lara | |
dc.contributor.author | Malcolm, William F. | |
dc.contributor.author | D’Angio, Carl T. | |
dc.contributor.author | Ohls, Robin K. | |
dc.contributor.author | Poindexter, Brenda B. | |
dc.contributor.author | Sokol, Gregory M. | |
dc.contributor.author | Van Meurs, Krisa P. | |
dc.contributor.author | Colaizy, Tarah T. | |
dc.contributor.author | Khmour, Ayman | |
dc.contributor.author | Puopolo, Karen M. | |
dc.contributor.author | Garg, Meena | |
dc.contributor.author | Walsh, Michele C. | |
dc.contributor.department | Pediatrics, School of Medicine | en_US |
dc.date.accessioned | 2019-07-01T18:15:23Z | |
dc.date.available | 2019-07-01T18:15:23Z | |
dc.date.issued | 2019-01 | |
dc.description.abstract | OBJECTIVE: To assess whether length of hospital stay is decreased among moderately preterm infants weaned from incubator to crib at a lower vs higher weight. STUDY DESIGN: This trial was conducted in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Infants with gestational ages 29-33 weeks, birthweight <1600 g, and in an incubator were randomly assigned to a weaning weight of 1600 or 1800 g. Within 60 to 100 g of weaning weight, the incubator temperature was decreased by 1.0°C to 1.5°C every 24 hours until 28.0°C. The infants were weaned to the crib following stable temperature at 36.5°C to 37.4°C for 8 to 12 hours. Clothing and bedcoverings were standardized. The primary outcome was length of hospital stay from birth to discharge; secondary outcomes included length of stay and growth velocity from weaning to discharge. Adverse events were monitored. RESULTS: Of 1565 infants screened, 885 were eligible, and 366 enrolled-187 to the 1600-g and 179 to the 1800-g group. Maternal and neonatal characteristics did not differ among weight groups. Length of hospital stay was a median of 43 days in the lower and 41 days in the higher weight group (P = .12). Growth velocity from completion of weaning to discharge was higher in the lower weight group, 13.7 g/kg/day vs 12.8 g/kg/day (P = .005). Groups did not differ in adverse events. CONCLUSIONS: Among moderately preterm neonates, weaning from incubator to crib at a lower weight did not decrease length of stay, but was safe and was accompanied by higher weight gain after weaning. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Shankaran, S., Bell, E. F., Laptook, A. R., Saha, S., Newman, N. S., Kazzi, S., … Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research Network (2019). Weaning of Moderately Preterm Infants from the Incubator to the Crib: A Randomized Clinical Trial. The Journal of pediatrics, 204, 96–102.e4. doi:10.1016/j.jpeds.2018.08.079 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/19778 | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.jpeds.2018.08.079 | en_US |
dc.relation.journal | The Journal of Pediatrics | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Incubator | en_US |
dc.subject | Moderately preterm infants | en_US |
dc.subject | Randomized controlled trial | en_US |
dc.subject | Temperature | en_US |
dc.subject | Weaning | en_US |
dc.title | Weaning of Moderately Preterm Infants from the Incubator to the Crib: A Randomized Clinical Trial | en_US |
dc.type | Article | en_US |