Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome

dc.contributor.authorDoan, Khanh Duy
dc.contributor.authorAkinsanya, Adeyinka
dc.contributor.authorKuhar, Matthew
dc.contributor.authorMesa, Hector
dc.contributor.departmentPathology and Laboratory Medicine, School of Medicine
dc.date.accessioned2024-03-22T12:39:19Z
dc.date.available2024-03-22T12:39:19Z
dc.date.issued2023-10-25
dc.description.abstractDrug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare but severe and sometimes fatal adverse drug reaction that is known to occur with a number of antiepileptic drugs. It often follows a prolonged clinical course, which can worsen even after discontinuing the causative drug and administering steroid treatment. Failure to promptly identify the delayed involvement of vital organs, such as the heart and liver, may result in irreversible organ failure and death. We report a case of a presumed sudden death of a young woman who had a documented history of a protracted intermittent hypersensitivity reaction to lamotrigine. Postmortem examination revealed the presence of eosinophilic myocarditis and submassive hepatic necrosis diagnostic of fatal DRESS syndrome that progressed despite early discontinuation of the medication and improvement of dermatologic and hematologic symptoms following steroid therapy.
dc.eprint.versionFinal published version
dc.identifier.citationDoan KD, Akinsanya A, Kuhar M, Mesa H. Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome. Allergy Asthma Clin Immunol. 2023;19(1):92. Published 2023 Oct 25. doi:10.1186/s13223-023-00848-6
dc.identifier.urihttps://hdl.handle.net/1805/39425
dc.language.isoen_US
dc.publisherBMC
dc.relation.isversionof10.1186/s13223-023-00848-6
dc.relation.journalAllergy, Asthma & Clinical Immunology
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePMC
dc.subjectLamotrigine
dc.subjectDrug hypersensitivity syndrome
dc.subjectMyocarditis
dc.subjectMassive hepatic necrosis
dc.subjectThyroiditis
dc.subjectAutopsy
dc.titleFatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
13223_2023_Article_848.pdf
Size:
1.11 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.99 KB
Format:
Item-specific license agreed upon to submission
Description: