Cancer History: A Predictor of IPMN Subtype and Dysplastic Status?
| dc.contributor.author | Carr, Rosalie A. | |
| dc.contributor.author | Kiel, Brandon A. | |
| dc.contributor.author | Roch, Alexandra M. | |
| dc.contributor.author | Ceppa, Eugene P. | |
| dc.contributor.author | House, Michael G. | |
| dc.contributor.author | Zyromski, Nicholas J. | |
| dc.contributor.author | Nakeeb, Attila | |
| dc.contributor.author | Schmidt, C. Max | |
| dc.contributor.department | Surgery, School of Medicine | en_US |
| dc.date.accessioned | 2017-12-22T14:22:57Z | |
| dc.date.available | 2017-12-22T14:22:57Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | Introduction The aim of this study was to determine the association of PMH and FH of pancreatic (PDAC) and non-pancreatic cancers with IPMN malignant risk. Methods A retrospective review of a prospective database of IPMN patients undergoing resection was performed to assess FH and PMH. Results FH of PDAC was present in 13% of 362 included patients. Of these, 8% had at least one first degree relative (FDR) with PDAC. The rate of PDAC positive FH in non-invasive versus invasive IPMN patients was 14% and 8%, respectively (p = 0.3). In main duct IPMN patients, FH (44%) and PMH of non-pancreatic cancer (16%) was higher than that seen in branch duct IPMN (FH 29%; PMH 6%; p = 0.004 and 0.008). Conclusions FH of PDAC is not associated with IPMN malignant progression. FH and PMH of non-pancreatic cancer is associated with main duct IPMN, the subtype with the highest rate of invasive transformation. | en_US |
| dc.eprint.version | Author's manuscript | en_US |
| dc.identifier.citation | Carr, R. A., Kiel, B. A., Roch, A. M., Ceppa, E. P., House, M. G., Zyromski, N. J., … Schmidt, C. M. (2017). Cancer history: A predictor of IPMN subtype and dysplastic status? The American Journal of Surgery. https://doi.org/10.1016/j.amjsurg.2017.11.014 | en_US |
| dc.identifier.uri | https://hdl.handle.net/1805/14900 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.isversionof | 10.1016/j.amjsurg.2017.11.014 | en_US |
| dc.relation.journal | The American Journal of Surgery | en_US |
| dc.rights | Publisher Policy | en_US |
| dc.source | Author | en_US |
| dc.subject | IPMN | en_US |
| dc.subject | family history | en_US |
| dc.subject | pancreatic ductal adenocarcinoma | en_US |
| dc.title | Cancer History: A Predictor of IPMN Subtype and Dysplastic Status? | en_US |
| dc.type | Article | en_US |