GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer’s disease implicates microglial activation gene IL1RAP.

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dc.contributor.authorRamanan, Vijay K.
dc.contributor.authorRisacher, Shannon L.
dc.contributor.authorNho, Kwangsik
dc.contributor.authorKim, Sungeun
dc.contributor.authorShen, Li
dc.contributor.authorMcDonald, Brenna C.
dc.contributor.authorYoder, Karmen K.
dc.contributor.authorHutchins, Gary D.
dc.contributor.authorWest, John D.
dc.contributor.authorTallman, Eileen F.
dc.contributor.authorGao, Sujuan
dc.contributor.authorForoud, Tatiana M.
dc.contributor.authorFarlow, Martin R.
dc.contributor.authorDe Jager, Philip L.
dc.contributor.authorBennett, David A.
dc.contributor.authorAisen, Paul S.
dc.contributor.authorPetersen, Ronald C.
dc.contributor.authorJack, Clifford R.
dc.contributor.authorToga, Arthur W.
dc.contributor.authorGreen, Robert C.
dc.contributor.authorJagust, William J.
dc.contributor.authorWeiner, Michael W.
dc.contributor.authorSaykin, Andrew J.
dc.contributor.departmentDepartment of Medical and Molecular Genetics, IU School of Medicineen_US
dc.date.accessioned2016-12-15T22:29:49Z
dc.date.available2016-12-15T22:29:49Z
dc.date.issued2015-10
dc.description.abstractIn a genome-wide study, Ramanan et al. discover an association between the microglial activation gene IL1RAP and higher rates of amyloid plaque accumulation as measured by PET in prodromal Alzheimer’s disease. Activated microglia may be crucial in amyloid clearance, and targeting the interleukin-1/IL1RAP pathway may be a potential therapeutic approach.en_US
dc.eprint.versionPublished versionen_US
dc.identifier.citationRamanan, V. K., Risacher, S. L., Nho, K., Kim, S., Shen, L., McDonald, B. C., … Alzheimer’s Disease Neuroimaging Initiative (ADNI). (2015). GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer’s disease implicates microglial activation gene IL1RAP. Brain: A Journal of Neurology, 138(Pt 10), 3076–3088. http://doi.org/10.1093/brain/awv231en_US
dc.identifier.issn0006-8950 1460-2156en_US
dc.identifier.urihttps://hdl.handle.net/1805/11625
dc.language.isoen_USen_US
dc.publisherOxford UPen_US
dc.relation.isversionof10.1093/brain/awv231en_US
dc.relation.journalBrainen_US
dc.rightsPublisher's Policyen_US
dc.sourcePMCen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectamyloiden_US
dc.subjectgeneticsen_US
dc.subjectinterleukin-1en_US
dc.subjectmicrogliaen_US
dc.titleGWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer’s disease implicates microglial activation gene IL1RAP.en_US
dc.typeArticleen_US
ul.alternative.fulltexthttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671479/en_US
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