Novel Use of Folate-Targeted Intraoperative Fluorescence, OTL38, in Robot-Assisted Laparoscopic Partial Nephrectomy: Report of the First Three Cases
dc.contributor.author | Shum, Cheuk Fan | |
dc.contributor.author | Bahler, Clinton D. | |
dc.contributor.author | Low, Philip S. | |
dc.contributor.author | Ratliff, Timothy L. | |
dc.contributor.author | Kheyfets, Steven V. | |
dc.contributor.author | Natarajan, Jay P. | |
dc.contributor.author | Sandusky, George E. | |
dc.contributor.author | Sundaram, Chandru P. | |
dc.contributor.department | Department of Urology, IU School of Medicine | en_US |
dc.date.accessioned | 2017-08-08T18:30:04Z | |
dc.date.available | 2017-08-08T18:30:04Z | |
dc.date.issued | 2016 | |
dc.description.abstract | Partial nephrectomy is now the preferred surgical option for small renal tumors because it allows nephron preservation without compromising oncologic clearance. Its outcomes depend on the surgeon's ability to continuously identify the edges of the tumor during resection, thus leaving an adequate margin around the tumor without excessive removal of normal parenchyma, as well as keeping a short ischemic time. Folate receptors are highly abundant in the normal kidney, and there is a difference in folate receptor expression between malignant and normal renal tissues. Thus, the use of fluorescent agents that target folate receptors should result in differential fluorescence between the tumor and surrounding parenchyma during partial nephrectomy, which, in turn, helps tumor demarcation for identification and resection. A phase 2 study on the novel use of OTL38 in robot-assisted laparoscopic partial nephrectomy is currently in progress in our institution. The outcomes of the first three cases have shown the possible advantages of OTL38 in intraoperative tumor identification before resection and recognition of residual disease in the surrounding parenchyma after resection. The tumors typically appeared dark while the surrounding parenchyma showed brighter fluorescence. Immediately after tumor resection, the margins of all the specimens appeared to have a uniformly bright fluorescence, suggestive of an intact margin of normal renal parenchyma along the plane of excision. The pattern of intraoperative fluorescence correlates well with immunohistochemistry. No OTL38-related adverse effects have been seen among these three patients. We present the outcomes of these three cases, illustrated with intraoperative and immunohistochemistry images. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Shum, C. F., Bahler, C. D., Low, P. S., Ratliff, T. L., Kheyfets, S. V., Natarajan, J. P., … Sundaram, C. P. (2016). Novel Use of Folate-Targeted Intraoperative Fluorescence, OTL38, in Robot-Assisted Laparoscopic Partial Nephrectomy: Report of the First Three Cases. Journal of Endourology Case Reports, 2(1), 189–197. http://doi.org/10.1089/cren.2016.0104 | en_US |
dc.identifier.issn | 2379-9889 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/13755 | |
dc.language.iso | en_US | en_US |
dc.publisher | Mary Ann Liebert | en_US |
dc.relation.isversionof | 10.1089/cren.2016.0104 | en_US |
dc.relation.journal | Journal of Endourology Case Reports | en_US |
dc.rights | Attribution 3.0 United States | |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | |
dc.source | PMC | en_US |
dc.subject | OTL38 | en_US |
dc.subject | folate-targeted intraoperative fluorescence | en_US |
dc.subject | partial nephrectomy | en_US |
dc.title | Novel Use of Folate-Targeted Intraoperative Fluorescence, OTL38, in Robot-Assisted Laparoscopic Partial Nephrectomy: Report of the First Three Cases | en_US |
dc.type | Article | en_US |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- cren.2016.0104.pdf
- Size:
- 1.05 MB
- Format:
- Adobe Portable Document Format
- Description:
- Final published version
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.88 KB
- Format:
- Item-specific license agreed upon to submission
- Description: