The microenvironment matters: estrogen deficiency fuels cancer bone metastases

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dc.contributor.authorWright, Laura E.
dc.contributor.authorGuise, Theresa A.
dc.contributor.departmentDepartment of Medicine, IU School of Medicineen_US
dc.date.accessioned2016-04-20T16:15:48Z
dc.date.available2016-04-20T16:15:48Z
dc.date.issued2014-06-01
dc.description.abstractFactors released during osteoclastic bone resorption enhance disseminated breast cancer cell progression by stimulating invasiveness, growth, and a bone-resorptive phenotype in cancer cells. Postmenopausal bone loss may accelerate progression of breast cancer growth in bone, explaining the anticancer benefit of the bone-specific antiresorptive agent zoledronic acid in the postmenopausal setting. Clin Cancer Res; 20(11); 2817-9. ©2014 AACR.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationWright, L. E., & Guise, T. A. (2014). The Microenvironment Matters: Estrogen Deficiency Fuels Cancer Bone Metastases. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 20(11), 2817–2819. http://doi.org/10.1158/1078-0432.CCR-14-0576en_US
dc.identifier.issn1078-0432en_US
dc.identifier.urihttps://hdl.handle.net/1805/9350
dc.language.isoen_USen_US
dc.publisherAmerican Association for Cancer Researchen_US
dc.relation.isversionof10.1158/1078-0432.CCR-14-0576en_US
dc.relation.journalClinical Cancer Research: An Official Journal of the American Association for Cancer Researchen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectBone Neoplasmsen_US
dc.subjectsecondaryen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectpathologyen_US
dc.subjectEstrogensen_US
dc.subjectdeficiencyen_US
dc.subjectOsteoporosis, Postmenopausalen_US
dc.subjectTumor Microenvironmenten_US
dc.titleThe microenvironment matters: estrogen deficiency fuels cancer bone metastasesen_US
dc.typeArticleen_US
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