Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial

Simple item page
dc.contributor.authorAdams-Chapman, Ira
dc.contributor.authorWatterberg, Kristi L.
dc.contributor.authorNolen, Tracy L.
dc.contributor.authorHirsch, Shawn
dc.contributor.authorCole, Carol A.
dc.contributor.authorCotten, C. Michael
dc.contributor.authorOh, William
dc.contributor.authorPoindexter, Brenda B.
dc.contributor.authorZaterka-Baxter, Kristin M.
dc.contributor.authorDas, Abhik
dc.contributor.authorBackstrom Lacy, Conra
dc.contributor.authorScorsone, Ann Marie
dc.contributor.authorDuncan, Andrea F.
dc.contributor.authorDeMauro, Sara B.
dc.contributor.authorGoldstein, Ricki F.
dc.contributor.authorColaizy, Tarah T.
dc.contributor.authorWilson-Costello, Deanne E.
dc.contributor.authorPurdy, Isabell B.
dc.contributor.authorHintz, Susan R.
dc.contributor.authorHeyne, Roy J.
dc.contributor.authorMyers, Gary J.
dc.contributor.authorFuller, Janell
dc.contributor.authorMerhar, Stephanie
dc.contributor.authorHarmon, Heidi M.
dc.contributor.authorPeralta-Carcelen, Myriam
dc.contributor.authorKilbride, Howard W.
dc.contributor.authorMaitre, Nathalie L.
dc.contributor.authorVohr, Betty R.
dc.contributor.authorNatarajan, Girija
dc.contributor.authorMintz-Hittner, Helen
dc.contributor.authorQuinn, Graham E.
dc.contributor.authorWallace, David K.
dc.contributor.authorOlson, Richard J.
dc.contributor.authorOrge, Faruk H.
dc.contributor.authorTsui, Irena
dc.contributor.authorGaynon, Michael
dc.contributor.authorHutchinson, Amy K.
dc.contributor.authorHe, Yu-Guang
dc.contributor.authorWinter, Timothy W.
dc.contributor.authorYang, Michael B.
dc.contributor.authorHaider, Kathryn M.
dc.contributor.authorCogen, Martin S.
dc.contributor.authorHug, Denise
dc.contributor.authorBremer, Don L.
dc.contributor.authorDonahue, John P.
dc.contributor.authorLucas, William R.
dc.contributor.authorPhelps, Dale L.
dc.contributor.authorHiggins, Rosemary D.
dc.contributor.authorEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
dc.contributor.departmentPediatrics, School of Medicine
dc.date.accessioned2023-08-11T20:10:56Z
dc.date.available2023-08-11T20:10:56Z
dc.date.issued2021
dc.description.abstractObjective: This study evaluates the 24-month follow-up for the NICHD Neonatal Research Network (NRN) Inositol for Retinopathy Trial. Study design: Bayley Scales of Infants Development-III and a standardized neurosensory examination were performed in infants enrolled in the main trial. Moderate/severe NDI was defined as BSID-III Cognitive or Motor composite score <85, moderate or severe cerebral palsy, blindness, or hearing loss that prevents communication despite amplification were assessed. Results: Primary outcome was determined for 605/638 (95%). The mean gestational age was 25.8 ± 1.3 weeks and mean birthweight was 805 ± 192 g. Treatment group did not affect the risk for the composite outcome of death or survival with moderate/severe NDI (60% vs 56%, p = 0.40). Conclusions: Treatment group did not affect the risk of death or survival with moderate/severe NDI. Despite early termination, this study represents the largest RCT of extremely preterm infants treated with myo-inositol with neurodevelopmental outcome data.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationAdams-Chapman I, Watterberg KL, Nolen TL, et al. Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial. J Perinatol. 2021;41(8):2072-2087. doi:10.1038/s41372-021-01018-5
dc.identifier.urihttps://hdl.handle.net/1805/34862
dc.language.isoen_US
dc.publisherSpringer Nature
dc.relation.isversionof10.1038/s41372-021-01018-5
dc.relation.journalJournal of Perinatology
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectCerebral Palsy
dc.subjectChild development
dc.subjectGestational age
dc.subjectExtremely premature infant
dc.subjectInositol
dc.titleNeurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
nihms-1710302.pdf
Size:
985.51 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.99 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Access Policy Articles
Department of Pediatrics Works