Epigenetic Attire in Ovarian Cancer: The Emperor’s New Clothes

dc.contributor.authorMatei, Daniela
dc.contributor.authorNephew, Kenneth P.
dc.contributor.departmentAnatomy and Cell Biology, School of Medicineen_US
dc.date.accessioned2022-07-15T19:47:26Z
dc.date.available2022-07-15T19:47:26Z
dc.date.issued2020-09-15
dc.description.abstractOvarian cancer is an aggressive epithelial tumor that remains a major cause of cancer morbidity and mortality in women. Epigenetic alterations including DNA methylation and histone modifications are being characterized in ovarian cancer and have been functionally linked to processes involved in tumor initiation, chemotherapy resistance, cancer stem cell survival, and tumor metastasis. The epigenetic traits of cancer cells and of associated tumor microenvironment components have been shown to promote an immunosuppressive tumor milieu. However, DNA methylation and histone modifications are reversible, and therapies targeting the epigenome have been implicated in potential reinvigoration of the antitumor immunity. In this review, we provide an overview specifically of DNA methylation and histone modifications as "clothes of the ovarian cancer genome" in relationship to their functional effects and highlight recent developments in the field. We also address the clinical implications of therapeutic strategies to remove or alter specific articles of genomic "clothing" and restore normal cellular function. As the clothes of the genome continue to be deciphered, we envision that the epigenome will become an important therapeutic target for cancer.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationMatei D, Nephew KP. Epigenetic Attire in Ovarian Cancer: The Emperor's New Clothes. Cancer Res. 2020;80(18):3775-3785. doi:10.1158/0008-5472.CAN-19-3837en_US
dc.identifier.urihttps://hdl.handle.net/1805/29598
dc.language.isoen_USen_US
dc.publisherAmerican Association for Cancer Researchen_US
dc.relation.isversionof10.1158/0008-5472.CAN-19-3837en_US
dc.relation.journalCancer Researchen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectDNA methylationen_US
dc.subjectEnzyme inhibitorsen_US
dc.subjectHistone deacetylase inhibitorsen_US
dc.subjectNicotinamide N-Methyltransferaseen_US
dc.titleEpigenetic Attire in Ovarian Cancer: The Emperor’s New Clothesen_US
dc.typeArticleen_US
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