Adeno-Associated Viral Vectors in Neuroscience Research

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dc.contributor.authorHaggerty, David L.
dc.contributor.authorGrecco, Gregory G.
dc.contributor.authorReeves, Kaitlin C.
dc.contributor.authorAtwood, Brady
dc.contributor.departmentPharmacology and Toxicology, School of Medicineen_US
dc.date.accessioned2020-03-12T16:40:56Z
dc.date.available2020-03-12T16:40:56Z
dc.date.issued2020-06-12
dc.description.abstractAdeno-associated viral vectors (AAVs) are increasingly useful preclinical tools in neuroscience research studies for interrogating cellular and neurocircuit functions and mapping brain connectivity. Clinically, AAVs are showing increasing promise as viable candidates for treating multiple neurological diseases. Here, we briefly review the utility of AAVs in mapping neurocircuits, manipulating neuronal function and gene expression, and activity labeling in preclinical research studies as well as AAV-based gene therapies for diseases of the nervous system. This review highlights the vast potential that AAVs have for transformative research and therapeutics in the neurosciences.en_US
dc.identifier.citationHaggerty, D. L., Grecco, G. G., Reeves, K. C., & Atwood, B. (2019). Adeno-associated viral vectors in neuroscience research. Molecular Therapy-Methods & Clinical Development. 10.1016/j.omtm.2019.11.012en_US
dc.identifier.issn2329-0501en_US
dc.identifier.urihttps://hdl.handle.net/1805/22296
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.omtm.2019.11.012en_US
dc.relation.journalMolecular Therapy - Methods and Clinical Developmenten_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourcePMCen_US
dc.subjectViral Vectorsen_US
dc.subjectAdeno-associated viral vectorsen_US
dc.subjectNeuroscience Researchen_US
dc.subjectPreclinical toolsen_US
dc.titleAdeno-Associated Viral Vectors in Neuroscience Researchen_US
dc.typeArticleen_US
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