Monitoring focal adhesion kinase phosphorylation dynamics in live cells
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Date
2017-07-24
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American English
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Royal Society of Chemistry
Abstract
Focal adhesion kinase (FAK) is a cytoplasmic non-receptor tyrosine kinase essential for a diverse set of cellular functions. Current methods for monitoring FAK activity in response to an extracellular stimulus lack spatiotemporal resolution and/or the ability to perform multiplex detection. Here we report on a novel approach to monitor the real-time kinase phosphorylation activity of FAK in live single cells by fluorescence lifetime imaging.
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Damayanti, N. P., Buno, K., Narayanan, N., Voytik Harbin, S. L., Deng, M., & Irudayaraj, J. (2017). Monitoring focal adhesion kinase phosphorylation dynamics in live cells. The Analyst, 142(15), 2713–2716. doi:10.1039/c7an00471k
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The Analyst
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PMC
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