Frequency, Characteristics and Complications of COVID-19 in Hospitalized Infants
dc.contributor.author | Hobbs, Charlotte V. | |
dc.contributor.author | Woodworth, Kate | |
dc.contributor.author | Young, Cameron C. | |
dc.contributor.author | Jackson, Ashley M. | |
dc.contributor.author | Newhams, Margaret M. | |
dc.contributor.author | Dapul, Heda | |
dc.contributor.author | Maamari, Mia | |
dc.contributor.author | Hall, Mark W. | |
dc.contributor.author | Maddux, Aline B. | |
dc.contributor.author | Sing, Aalok R. | |
dc.contributor.author | Schuster, Jennifer E. | |
dc.contributor.author | Rowan, Courtney M. | |
dc.contributor.author | Fitzgerald, Julie C. | |
dc.contributor.author | Irby, Katherine | |
dc.contributor.author | Kong, Michele | |
dc.contributor.author | Mack, Elizabeth H. | |
dc.contributor.author | Staat, Mary A. | |
dc.contributor.author | Cvijanovich, Natalie Z. | |
dc.contributor.author | Bembea, Melania M. | |
dc.contributor.author | Coates, Bria M. | |
dc.contributor.author | Halasa, Natasha B. | |
dc.contributor.author | Walker, Tracie C. | |
dc.contributor.author | McLaughlin, Gwenn E. | |
dc.contributor.author | Babbitt, Christopher J. | |
dc.contributor.author | Nofziger, Ryan A. | |
dc.contributor.author | Loftis, Laura L. | |
dc.contributor.author | Bradford, Tamara T. | |
dc.contributor.author | Campbell, Angela P. | |
dc.contributor.author | Patel, Manish M. | |
dc.contributor.author | Randolph, Adrienne G. | |
dc.contributor.author | Overcoming COVID-19 Investigators | |
dc.contributor.department | Pediatrics, School of Medicine | en_US |
dc.date.accessioned | 2023-05-10T10:25:34Z | |
dc.date.available | 2023-05-10T10:25:34Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Background: Previous studies of severe acute respiratory syndrome coronavirus 2 infection in infants have incompletely characterized factors associated with severe illness or focused on infants born to mothers with coronavirus disease 2019 (COVID-19). Here we highlight demographics, clinical characteristics and laboratory values that differ between infants with and without severe acute COVID-19. Methods: Active surveillance was performed by the Overcoming COVID-19 network to identify children and adolescents with severe acute respiratory syndrome coronavirus 2-related illness hospitalized at 62 sites in 31 states from March 15 to December 27, 2020. We analyzed patients >7 days to <1 year old hospitalized with symptomatic acute COVID-19. Results: We report 232 infants >7 days to <1 year of age hospitalized with acute symptomatic COVID-19 from 37 US hospitals in our cohort from March 15 to December 27, 2020. Among 630 cases of severe COVID-19 in patients >7 days to <18 years old, 128 (20.3%) were infants. In infants with severe illness from the entire study period, the median age was 2 months, 66% were from racial and ethnic minority groups, 66% were previously healthy, 73% had respiratory complications, 13% received mechanical ventilation and <1% died. Conclusions: Infants accounted for over a fifth of children <18 years of age hospitalized for severe acute COVID-19, commonly manifesting with respiratory symptoms and complications. Although most infants hospitalized with COVID-19 did not suffer significant complications, longer term outcomes remain unclear. Notably, 75% of infants with severe disease were <6 months of age in this cohort study period, which predated maternal COVID-19 vaccination, underscoring the importance of maternal vaccination for COVID-19 in protecting the mother and infant. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Hobbs CV, Woodworth K, Young CC, et al. Frequency, Characteristics and Complications of COVID-19 in Hospitalized Infants. Pediatr Infect Dis J. 2022;41(3):e81-e86. doi:10.1097/INF.0000000000003435 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/32884 | |
dc.language.iso | en_US | en_US |
dc.publisher | Wolters Kluwer | en_US |
dc.relation.isversionof | 10.1097/INF.0000000000003435 | en_US |
dc.relation.journal | The Pediatric Infectious Disease Journal | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Infant | en_US |
dc.subject | Hospitalized | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.title | Frequency, Characteristics and Complications of COVID-19 in Hospitalized Infants | en_US |
dc.type | Article | en_US |
ul.alternative.fulltext | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828316/ | en_US |