Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life
dc.contributor.author | Tabilas, Cybelle | |
dc.contributor.author | Wang, Jocelyn | |
dc.contributor.author | Liu, Xiaojing | |
dc.contributor.author | Locasale, Jason W. | |
dc.contributor.author | Smith, Norah L. | |
dc.contributor.author | Rudd, Brian D. | |
dc.contributor.department | Pediatrics, School of Medicine | en_US |
dc.date.accessioned | 2021-12-13T19:20:35Z | |
dc.date.available | 2021-12-13T19:20:35Z | |
dc.date.issued | 2019-11-15 | |
dc.description.abstract | Neonates often develop poor immunity against intracellular pathogens. Because CD8+ T cells are essential for eliminating infectious agents, it is crucial to understand why they behave differently in early life. Previous studies in mice have demonstrated that neonatal CD8+ T cells fail to form memory because of an intrinsic propensity to differentiate into short-lived effectors. However, the underlying mechanisms remain undefined. We now show that neonatal CD8+ T cells exhibit higher glycolytic activity than adult CD8+ T cells postinfection, which may be due to age-related differences in Lin28b expression. Importantly, when glycolysis is pharmacologically inhibited, the impaired formation of neonatal memory CD8+ T cells can be restored. Collectively, these data suggest that neonatal CD8+ T cells are inherently biased toward undergoing glycolytic metabolism postinfection, which compromises their ability to develop into memory CD8+ T cells in early life. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Tabilas, C., Wang, J., Liu, X., Locasale, J. W., Smith, N. L., & Rudd, B. D. (2019). Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life. Journal of Immunology (Baltimore, Md.: 1950), 203(10), 2571–2576. https://doi.org/10.4049/jimmunol.1900426 | en_US |
dc.identifier.issn | 1550-6606 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/27156 | |
dc.language.iso | en | en_US |
dc.publisher | American Association of Immunologists | en_US |
dc.relation.isversionof | 10.4049/jimmunol.1900426 | en_US |
dc.relation.journal | Journal of Immunology | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Adoptive Transfer | en_US |
dc.subject | Animals | en_US |
dc.subject | CD8-Positive T-Lymphocytes | en_US |
dc.title | Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life | en_US |
dc.type | Article | en_US |