Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition
| dc.contributor.author | Masood, Ashiq | |
| dc.contributor.author | Christ, Trevor | |
| dc.contributor.author | Asif, Samia | |
| dc.contributor.author | Rajakumar, Priya | |
| dc.contributor.author | Gustafson, Beth A. | |
| dc.contributor.author | Shune, Leyla O. | |
| dc.contributor.author | Salahudeen, Ameen | |
| dc.contributor.author | Nedvad, Drew | |
| dc.contributor.author | Nanua, Suparna | |
| dc.contributor.author | Paner, Agne | |
| dc.contributor.author | Kuzel, Timothy M. | |
| dc.contributor.author | Levy, Mia | |
| dc.contributor.author | Subramanian, Janakiraman | |
| dc.contributor.author | Raza, Shahzad | |
| dc.contributor.department | Medicine, School of Medicine | |
| dc.date.accessioned | 2025-03-11T12:57:25Z | |
| dc.date.available | 2025-03-11T12:57:25Z | |
| dc.date.issued | 2021-03-17 | |
| dc.description.abstract | Non-secretory multiple myeloma (NSMM) constitutes a distinct entity of multiple myeloma characterized by the absence of detectable monoclonal protein and rarely an absence of free light chains in the serum and urine. Given its rarity, the genomic landscape, clinical course, and prognosis of NSSM are not well characterized. Here, we report a case of a patient with relapsed and refractory NSMM with brain metastasis harboring a TFG-ALK fusion showing a dramatic and durable (over two years) response to commercially available anaplastic lymphoma kinase (ALK) inhibitors. The case emphasizes the beneficial role of molecular profiling in this target-poor disease. | |
| dc.eprint.version | Final published version | |
| dc.identifier.citation | Masood A, Christ T, Asif S, et al. Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition. NPJ Genom Med. 2021;6(1):23. Published 2021 Mar 17. doi:10.1038/s41525-021-00186-9 | |
| dc.identifier.uri | https://hdl.handle.net/1805/46311 | |
| dc.language.iso | en_US | |
| dc.publisher | Springer Nature | |
| dc.relation.isversionof | 10.1038/s41525-021-00186-9 | |
| dc.relation.journal | NPJ: Genomic Medicine | |
| dc.rights | Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.source | PMC | |
| dc.subject | Molecular medicine | |
| dc.subject | Cancer genomics | |
| dc.subject | Non-secretory multiple myeloma (NSMM) | |
| dc.title | Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition | |
| dc.type | Article |