The efficacy of low-dose aspirin in pregnancy among women in malaria-endemic countries

dc.contributor.authorBauserman, Melissa
dc.contributor.authorLeuba, Sequoia I.
dc.contributor.authorHemingway-Foday, Jennifer
dc.contributor.authorNolen, Tracy L.
dc.contributor.authorMoore, Janet
dc.contributor.authorMcClure, Elizabeth M.
dc.contributor.authorLokangaka, Adrien
dc.contributor.authorTsehfu, Antoinette
dc.contributor.authorPatterson, Jackie
dc.contributor.authorLiechty, Edward A.
dc.contributor.authorEsamai, Fabian
dc.contributor.authorCarlo, Waldemar A.
dc.contributor.authorChomba, Elwyn
dc.contributor.authorGoldenberg, Robert L.
dc.contributor.authorSaleem, Sarah
dc.contributor.authorJessani, Saleem
dc.contributor.authorKoso-Thomas, Marion
dc.contributor.authorHoffman, Matthew
dc.contributor.authorDerman, Richard J.
dc.contributor.authorMeshnick, Steven R.
dc.contributor.authorBose, Carl L.
dc.contributor.departmentPediatrics, School of Medicine
dc.date.accessioned2024-05-15T21:15:55Z
dc.date.available2024-05-15T21:15:55Z
dc.date.issued2022-04-10
dc.description.abstractBackground Low dose aspirin (LDA) is an effective strategy to reduce preterm birth. However, LDA might have differential effects globally, based on the etiology of preterm birth. In some regions, malaria in pregnancy could be an important modifier of LDA on birth outcomes and anemia. Methods This is a sub-study of the ASPIRIN trial, a multi-national, randomized, placebo controlled trial evaluating LDA effect on preterm birth. We enrolled a convenience sample of women in the ASPIRIN trial from the Democratic Republic of Congo (DRC), Kenya and Zambia. We used quantitative polymerase chain reaction to detect malaria. We calculated crude prevalence proportion ratios (PRs) for LDA by malaria for outcomes, and regression modelling to evaluate effect measure modification. We evaluated hemoglobin in late pregnancy based on malaria infection in early pregnancy. Results One thousand four hundred forty-six women were analyzed, with a malaria prevalence of 63% in the DRC site, 38% in the Kenya site, and 6% in the Zambia site. Preterm birth occurred in 83 (LDA) and 90 (placebo) women, (PR 0.92, 95% CI 0.70, 1.22), without interaction between LDA and malaria (p = 0.75). Perinatal mortality occurred in 41 (LDA) and 43 (placebo) pregnancies, (PR 0.95, 95% CI 0.63, 1.44), with an interaction between malaria and LDA (p = 0.014). Hemoglobin was similar by malaria and LDA status. Conclusions Malaria in early pregnancy did not modify the effects of LDA on preterm birth, but modified the effect of LDA on perinatal mortality. This effect measure modification deserves continued study as LDA is used in malaria endemic regions.
dc.eprint.versionFinal published version
dc.identifier.citationBauserman, M., Leuba, S. I., Hemingway-Foday, J., Nolen, T. L., Moore, J., McClure, E. M., Lokangaka, A., Tsehfu, A., Patterson, J., Liechty, E. A., Esamai, F., Carlo, W. A., Chomba, E., Goldenberg, R. L., Saleem, S., Jessani, S., Koso-Thomas, M., Hoffman, M., Derman, R. J., … Bose, C. L. (2022). The efficacy of low-dose aspirin in pregnancy among women in malaria-endemic countries. BMC Pregnancy and Childbirth, 22(1), 303. https://doi.org/10.1186/s12884-022-04652-9
dc.identifier.urihttps://hdl.handle.net/1805/40783
dc.language.isoen_US
dc.publisherSpringer
dc.relation.isversionof10.1186/s12884-022-04652-9
dc.relation.journalBMC Pregnancy and Childbirth
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePublisher
dc.subjectMalaria
dc.subjectPregnancy
dc.subjectPremature birth
dc.subjectPerinatal mortality
dc.titleThe efficacy of low-dose aspirin in pregnancy among women in malaria-endemic countries
dc.typeArticle
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