Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice

dc.contributor.authorSmoker, Michael P.
dc.contributor.authorMackie, Ken
dc.contributor.authorLapish, Christopher C.
dc.contributor.authorBoehm, Stephen L., II
dc.contributor.departmentPsychology, School of Scienceen_US
dc.date.accessioned2020-04-16T16:43:29Z
dc.date.available2020-04-16T16:43:29Z
dc.date.issued2019
dc.description.abstractBackground With increasing access to legal cannabis across the globe, it is imperative to more closely study its behavioral and physiological effects. Furthermore, with the proliferation of cannabis use, modes of consumption are changing, with edible formulations becoming increasingly popular. Nevertheless, there are relatively few animal models of self-administration of the primary psychoactive component of cannabis, Δ9-tetrahydrocannabinol (THC), and almost all incorporate routes of administration other than those used by humans. The aim of the current study was to develop a model of edible THC self-administration and assess its impact on CB1 receptor-mediated behaviors in female and male mice. Methods Mice were given limited access to a palatable dough which occasionally contained THC in doses ranging from 1 to 10 mg/kg. Following dough consumption, mice were assessed for home cage locomotor activity, body temperature, or analgesia. Locomotor activity was also assessed in conjunction with the CB1 receptor antagonist SR141716A. Results Dough was well-consumed, but consumption decreased at the highest THC concentrations. Edible THC produced dose-dependent decreases in locomotor activity and body temperature in both sexes, and these effects were more pronounced in male mice. Hypolocomotion induced by edible THC was attenuated by SR141716A, indicating mediation by CB1 receptor activation. Conclusions In contrast to other cannabinoid self-administration models, edible THC is relatively low in stress and uses a route of administration analogous to one used by humans. Potential applications include chronic THC self-administration, determining THC reward/reinforcement, and investigating consequences of oral THC use.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationSmoker, M. P., Mackie, K., Lapish, C. C., & Boehm, S. L. (2019). Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice. Drug and Alcohol Dependence, 199, 106–115. https://doi.org/10.1016/j.drugalcdep.2019.02.020en_US
dc.identifier.urihttps://hdl.handle.net/1805/22579
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.drugalcdep.2019.02.020en_US
dc.relation.journalDrug and Alcohol Dependenceen_US
dc.rightsPublisher Policyen_US
dc.sourcePublisheren_US
dc.subjectcannabinoiden_US
dc.subjectedibleen_US
dc.subjectself-administrationen_US
dc.titleSelf-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in miceen_US
dc.typeArticleen_US
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