Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein

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dc.contributor.authorZhang, Min
dc.contributor.authorMandraju, Rajakumar
dc.contributor.authorRai, Urvashi
dc.contributor.authorShiratsuchi, Takayuki
dc.contributor.authorTsuji, Moriya
dc.contributor.departmentPharmacology and Toxicology, School of Medicineen_US
dc.date.accessioned2020-01-02T15:05:53Z
dc.date.available2020-01-02T15:05:53Z
dc.date.issued2017-08-23
dc.description.abstractMalaria is a mosquito-borne infectious disease caused by the parasite Plasmodium spp. Malaria continues to have a devastating impact on human health. Sporozoites are the infective forms of the parasite inside mosquito salivary glands. Circumsporozoite protein (CSP) is a major and immunodominant protective antigen on the surface of Plasmodium sporozoites. Here, we report a generation of specific monoclonal antibodies that recognize the central repeat and C-terminal regions of P. falciparum CSP. The monoclonal antibodies 3C1, 3C2, and 3D3-specific for the central repeat region-have higher titers and protective efficacies against challenge with sporozoites compared with 2A10, a gold standard monoclonal antibody that was generated in early 1980s.en_US
dc.identifier.citationZhang, M., Mandraju, R., Rai, U., Shiratsuchi, T., & Tsuji, M. (2017). Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein. Antibodies (Basel, Switzerland), 6(3), 11. doi:10.3390/antib6030011en_US
dc.identifier.urihttps://hdl.handle.net/1805/21680
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isversionof10.3390/antib6030011en_US
dc.relation.journalAntibodiesen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourcePMCen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectCircumsporozoite proteinen_US
dc.subjectCSPen_US
dc.subjectMonoclonal antibodyen_US
dc.subject2A10en_US
dc.subject3C1en_US
dc.subject3C2en_US
dc.subject3D3en_US
dc.titleMonoclonal Antibodies against Plasmodium falciparum Circumsporozoite Proteinen_US
dc.typeArticleen_US
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