Co-recognition of β-glucan and chitin and programming of adaptive immunity to Aspergillus fumigatus

dc.contributor.authorAmarsaikhan, Nansalmaa
dc.contributor.authorTempleton, Steven P.
dc.contributor.departmentDepartment of Microbiology and Immunology, IU School of Medicineen_US
dc.date.accessioned2016-06-20T19:23:29Z
dc.date.available2016-06-20T19:23:29Z
dc.date.issued2015-04-21
dc.description.abstractThe prevalence of fungal infections has increased concurrently with increases in immune suppressive therapies and susceptible individuals. Opportunistic fungal pathogens such as Aspergillus fumigatus may exhibit invasive growth and dissemination resulting in a high mortality rate. Herein, we discuss how immune sensing of germination directs innate immune responses and programs adaptive responses that could promote or impair immune protection during periods of heightened susceptibility. In infected individuals, Th1 responses are the most protective, while Th2 responses lead to poor disease outcomes. In particular, the roles of β-glucan and chitin co-recognition in shaping Th1- and Th2-type immunity to fungal infection are explored. We discuss how fungal responses to environmental stresses could result in decreased immune protection from infection, particularly in response to anti-fungal drugs that target β-glucan synthesis. Furthermore, we consider how experimental modulation of host-pathogen interactions might elucidate the mechanisms of protective and detrimental immunity and the potential of current and future studies to promote the development of improved treatments for patients that respond poorly to existing therapies.en_US
dc.identifier.citationAmarsaikhan, N., & Templeton, S. P. (2015). Co-recognition of β-glucan and chitin and programming of adaptive immunity to Aspergillus fumigatus. Frontiers in Microbiology, 6, 344. http://doi.org/10.3389/fmicb.2015.00344en_US
dc.identifier.urihttps://hdl.handle.net/1805/10052
dc.language.isoen_USen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.isversionof10.3389/fmicb.2015.00344en_US
dc.relation.journalFrontiers in Microbiologyen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectAspergillus fumigatusen_US
dc.subjectAdaptive immunityen_US
dc.subjectAspergillosisen_US
dc.subjectCell wall modulationen_US
dc.subjectChitinen_US
dc.subjectFungal infectionen_US
dc.subjectInnate recognitionen_US
dc.subjectβ-glucanen_US
dc.titleCo-recognition of β-glucan and chitin and programming of adaptive immunity to Aspergillus fumigatusen_US
dc.typeArticleen_US
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