Trends of mutation accumulation across global SARS-CoV-2 genomes: Implications for the evolution of the novel coronavirus
dc.contributor.author | Roy, Chayan | |
dc.contributor.author | Mandal, Santi M. | |
dc.contributor.author | Mondal, Suresh K. | |
dc.contributor.author | Mukherjee, Shriparna | |
dc.contributor.author | Mapder, Tarunendu | |
dc.contributor.author | Ghosh, Wriddhiman | |
dc.contributor.author | Chakraborty, Ranadhir | |
dc.contributor.department | Medicine, School of Medicine | en_US |
dc.date.accessioned | 2021-04-09T19:30:34Z | |
dc.date.available | 2021-04-09T19:30:34Z | |
dc.date.issued | 2020-11 | |
dc.description.abstract | To understand SARS-CoV-2 microevolution, this study explored the genome-wide frequency, gene-wise distribution, and molecular nature of all point-mutations detected across its 71,703 RNA-genomes deposited in GISAID till 21 August 2020. Globally, nsp1/nsp2 and orf7a/orf3a were the most mutation-ridden non-structural and structural genes respectively. Phylogeny of 4618 spatiotemporally-representative genomes revealed that entities belonging to the early lineages are mostly spread over Asian countries, including India, whereas the recently-derived lineages are more globally distributed. Of the total 20,163 instances of polymorphism detected across global genomes, 12,594 and 7569 involved transitions and transversions, predominated by cytidine-to-uridine and guanosine-to-uridine conversions, respectively. Positive selection of nonsynonymous mutations (dN/dS >1) in most of the structural, but not the non-structural, genes indicated that SARS-CoV-2 has already harmonized its replication/transcription machineries with the host metabolism, while it is still redefining virulence/transmissibility strategies at the molecular level. Mechanistic bases and evolutionary/pathogenicity-related implications are discussed for the predominant mutation-types. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Roy, C., Mandal, S. M., Mondal, S. K., Mukherjee, S., Mapder, T., Ghosh, W., & Chakraborty, R. (2020). Trends of mutation accumulation across global SARS-CoV-2 genomes: Implications for the evolution of the novel coronavirus. Genomics, 112(6), 5331-5342. https://doi.org/10.1016/j.ygeno.2020.11.003 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/25614 | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.ygeno.2020.11.003 | en_US |
dc.relation.journal | Genomics | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.source | Publisher | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | genome-wide mutations | en_US |
dc.subject | transition | en_US |
dc.title | Trends of mutation accumulation across global SARS-CoV-2 genomes: Implications for the evolution of the novel coronavirus | en_US |
dc.type | Article | en_US |