Comparison of multi-shot and single shot echo-planar diffusion tensor techniques for the optic pathway in patients with neurofibromatosis type 1

dc.contributor.authorHo, Chang Y.
dc.contributor.authorDeardorff, Rachael
dc.contributor.authorKralik, Stephen F.
dc.contributor.authorWest, John D.
dc.contributor.authorWu, Yu-Chien
dc.contributor.authorShih, Chie-Schin
dc.contributor.departmentRadiology and Imaging Sciences, School of Medicineen_US
dc.date.accessioned2019-12-13T17:20:26Z
dc.date.available2019-12-13T17:20:26Z
dc.date.issued2019-04
dc.description.abstractPurpose Diffusion tensor imaging (DTI) may be helpful in assessing optic pathway integrity as a marker for treatment in neurofibromatosis type 1 (NF1) patients with optic gliomas (OG). However, susceptibility artifacts are common in typical single-shot echo planar imaging (ssDTI). A readout-segmented multi-shot EPI technique (rsDTI) was utilized to minimize susceptibility distortions of the skull base and improve quantitative metrics. Methods Healthy controls, children with NF1 without OG, and NF1 with OG ± visual symptoms were included. All subjects were scanned with both rsDTI and ssDTI sequences sequentially. Diffusion metrics and deterministic fiber tracking were calculated. Tract count, volume, and length were also compared by a two-factor mixed ANOVA. Results Five healthy controls, 7 NF1 children without OG, and 12 NF1 children with OG were imaged. Six OG patients had visual symptoms. Four subjects had no detectable optic pathway fibers on ssDTI due to susceptibility, for which rsDTI was able to delineate. Tract count (p < 0.001), tract volume (p < 0.001), and FA (P < 0.001) were significantly higher for rsDTI versus ssDTI for all subjects. MD (p < 0.001) and RD (p < 0.001) were significantly lower for rsDTI vs ssDTI. Finally, MD, AD, and RD had a significantly lower difference in NF1 children with visual symptoms compared to NF1 children without visual symptoms only on ssDTI scans. Conclusion DTI with readout-segmented multi-shot EPI technique can better visualize the optic pathway and allow more confident measurements of anisotropy in NF1 patients. This is shown by a significant increase in FA, tract count, and volume with rsDTI versus ssDTI.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationHo, C. Y., Deardorff, R., Kralik, S. F., West, J. D., Wu, Y.-C., & Shih, C.-S. (2019). Comparison of multi-shot and single shot echo-planar diffusion tensor techniques for the optic pathway in patients with neurofibromatosis type 1. Neuroradiology, 61(4), 431–441. https://doi.org/10.1007/s00234-019-02164-6en_US
dc.identifier.urihttps://hdl.handle.net/1805/21481
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s00234-019-02164-6en_US
dc.relation.journalNeuroradiologyen_US
dc.rightsPublisher Policyen_US
dc.sourceAuthoren_US
dc.subjectneurofibromatosis type 1en_US
dc.subjectoptic nerve gliomaen_US
dc.subjectdiffusion tensor imagingen_US
dc.titleComparison of multi-shot and single shot echo-planar diffusion tensor techniques for the optic pathway in patients with neurofibromatosis type 1en_US
dc.typeArticleen_US
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