Secondary data analysis investigating effects of marine omega-3 fatty acids on circulating levels of leptin and adiponectin in older adults

dc.contributor.authorRausch, J. A.
dc.contributor.authorGillespie, S.
dc.contributor.authorOrchard, T.
dc.contributor.authorTan, A.
dc.contributor.authorMcDaniel, J. C.
dc.contributor.departmentSchool of Nursing
dc.date.accessioned2025-03-31T15:30:13Z
dc.date.available2025-03-31T15:30:13Z
dc.date.issued2021
dc.description.abstractBackground: Higher leptin and lower adiponectin levels have been linked to progressing systemic inflammation and diseases of aging. Among older adults with obesity and an inflammatory conditions, we quantified effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on leptin, adiponectin, and the leptin-to-adiponectin ratio (LAR). We also examined associations among adipokine and cytokine levels. Methods: Using a randomized, double-blind, placebo-controlled design, participants (mean age 61.3 ± 2.1) received 1.5 g EPA + 1.0 g DHA (n = 14) or mineral oil (n = 18) daily. Plasma adipokine and cytokine levels were quantified by electrochemiluminescence at all study intervals. Results: While no between-group differences were detected, there was a reduction in the LAR (by 23%, p=.065) between weeks 4 and 8 among the EPA+DHA group. Adiponectin levels were negatively associated with IL-1β levels at week 4 (p=.02) and TNF-α levels at week 8 (p=.03). Conclusion: Potential benefits of EPA+DHA supplementation among aging populations warrant further study.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationRausch JA, Gillespie S, Orchard T, Tan A, McDaniel JC. Secondary data analysis investigating effects of marine omega-3 fatty acids on circulating levels of leptin and adiponectin in older adults. Prostaglandins Leukot Essent Fatty Acids. 2021;170:102302. doi:10.1016/j.plefa.2021.102302
dc.identifier.urihttps://hdl.handle.net/1805/46701
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isversionof10.1016/j.plefa.2021.102302
dc.relation.journalProstaglandins Leukotrienes and Essential Fatty Acids
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectLeptin
dc.subjectAdiponectin
dc.subjectLeptin-to-adiponectin ratio
dc.subjectInflammation
dc.titleSecondary data analysis investigating effects of marine omega-3 fatty acids on circulating levels of leptin and adiponectin in older adults
dc.typeArticle
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